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Simian virus 40 DNA in immunocompetent children with respiratory disease

Bahman Abedi Kiasari1, Fatemeh Hoda Fallah2, Mohammad Kazem Koohi3

  • 1Department of Virology, Faculty of Veterinary Medicine, University of Tehran, Tehran, Iran.

Journal of Medical Virology
|July 5, 2022
PubMed

Insights

Simian virus 40 (SV40) was detected in immunocompetent children with respiratory illness, suggesting the respiratory tract may be a transmission route or persistence site for this polyomavirus. Coinfections were common in these SV40 cases.

Area of Science:

  • Virology
  • Infectious Diseases
  • Public Health

Background:

  • Simian virus 40 (SV40) DNA and gene products have been found in various human organ systems.
  • The transmission routes and clinical significance of SV40 polyomavirus infection in humans remain unclear.
  • Understanding SV40 prevalence in respiratory illnesses is crucial for public health.

Purpose of the Study:

  • To determine the frequency of SV40 infection in immunocompetent and immunocompromised individuals with respiratory diseases.
  • To investigate the potential role of the respiratory tract in SV40 transmission or persistence.
  • To examine coinfections with other viruses in SV40-positive respiratory samples.

Main Methods:

  • Real-time PCR was used to screen 280 nasopharyngeal aspirate samples from patients with respiratory tract illness for SV40 polyomavirus.
  • Positive SV40 findings were confirmed using DNA sequencing.
  • Coinfection with other respiratory viruses was assessed in positive samples.

Main Results:

  • SV40 polyomavirus was detected in 2 out of 280 (0.71%) analyzed respiratory specimens.
  • The positive cases involved immunocompetent children aged 8 and 14 months with upper or lower respiratory tract infections.
  • Coinfections with other viruses were present in 50% of the SV40-positive samples.

Conclusions:

  • The findings indicate that SV40 can infect the human respiratory tract.
  • The respiratory tract may serve as a route for SV40 transmission or a site for viral persistence.
  • Given the high rate of coinfections, SV40's direct role in causing respiratory diseases requires further investigation.

Keywords:
coinfectionimmunocompetentpolyomavirusrespiratory infectionsimian virus 40

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