Structurally Modified Plant Viruses and Bacteriophages with Helical Structure. Properties and Applications
Olga A Kondakova1, Ekaterina A Evtushenko2, Oleg A Baranov1
1Faculty of Biology, Lomonosov Moscow State University, Moscow, 119234, Russia.
Biochemistry. Biokhimiia
|July 5, 2022
Summary
Structurally modified virus particles from plant viruses and bacteriophages offer promising biogenic platforms for biotechnology. This review covers their preparation, properties, biosafety, and applications in biomedicine, including vaccine design.
Area of Science:
- Biotechnology
- Virology
- Materials Science
Background:
- Rod-shaped or filamentous virions from plant viruses and bacteriophages can be structurally modified.
- These modified virus particles are emerging as versatile biogenic platforms.
- Recent research highlights their potential in novel biotechnologies.
Purpose of the Study:
- To review the preparation, structure, and properties of structurally modified virus particles.
- To assess the biosafety of these particles for animal applications.
- To explore their diverse applications in biomedicine, with a focus on vaccine development.
Main Methods:
- Thermal and chemical treatments are employed for structural modification of virions.
- Characterization of particle structure and properties.
- Evaluation of biosafety and potential biomedical applications.
Main Results:
- Structurally modified virus particles exhibit unique properties suitable for biotechnological applications.
- Demonstrated biosafety for animal models.
- Successful design of vaccine candidates based on modified plant viruses.
Conclusions:
- Structurally modified virus particles represent a promising class of nanomaterials for biotechnological innovation.
- Their versatility spans from fundamental research to advanced biomedical applications, particularly in vaccinology.
- Further research into their application is warranted to fully exploit their potential.
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