The value of myocardial work in assessment of ventricular function in patients with non-obstructive hypertrophic

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In Vivo Quantitative Assessment of Myocardial Structure, Function, Perfusion and Viability Using Cardiac Micro-computed Tomography
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In Vivo Quantitative Assessment of Myocardial Structure, Function, Perfusion and Viability Using Cardiac Micro-computed Tomography

Published on: February 16, 2016

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Chenguang Yang1, Ying Guo1, Xiang Wang1

  • 1Department of Cardiology, Beijing Hospital, National Center of Gerontology, Institute of Geriatric Medicine, Chinese Academy of Medical Sciences, No.1 Dahua Road, Dongdan, Dongcheng District, Beijing, 100730, China.

BMC Cardiovascular Disorders
|July 5, 2022
PubMed

Insights

Myocardial work assessment using speckle tracking echocardiography reveals impaired global work index, constructive work, and efficiency in non-obstructive hypertrophic cardiomyopathy (HCM) patients. This evaluation provides valuable insights into left ventricular function beyond traditional measures.

Area of Science:

  • Cardiology
  • Echocardiography
  • Cardiovascular Physiology

Background:

  • Non-obstructive hypertrophic cardiomyopathy (HCM) presents unique challenges in assessing left ventricular (LV) function.
  • Traditional echocardiographic parameters may not fully capture the functional impact of HCM.

Purpose of the Study:

  • To evaluate myocardial work parameters using speckle tracking echocardiography in patients with non-obstructive HCM.
  • To determine if myocardial work assessment provides additional diagnostic information in this patient cohort.

Main Methods:

  • Fifty patients with non-obstructive HCM and 50 healthy controls were enrolled.
  • Left ventricular ejection fraction (LVEF) was measured using bi-plane Simpson's method.
  • Myocardial work parameters, including global work index (GWI), global constructive work (GCW), global waste work (GWW), and global work efficiency (GWE), were derived from 2D strain-pressure loops.

Main Results:

  • Patients with non-obstructive HCM exhibited significantly decreased GWI, GCW, and GWE compared to controls.
  • Patients showed significantly increased GWW compared to controls.
  • A trend towards positive correlation between GWE and LVEF, and negative correlation between GWW and LVEF was observed in patients.
  • Maximal wall thickness significantly correlated with all myocardial work parameters.

Conclusions:

  • Myocardial work assessment using speckle tracking echocardiography offers valuable insights into LV function in patients with non-obstructive HCM.
  • These parameters can potentially identify subtle functional impairments not evident with standard echocardiography.
  • Further research is warranted to explore the clinical utility of myocardial work in managing HCM.
Abstract

Keywords:
EchocardiographyHypertrophic cardiomyopathyMyocardial workSpeckle tracking

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