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Paradoxical response to chest wall loading predicts a favorable mechanical response to reduction in tidal volume or

John Selickman¹, Pierre Tawfik², Philip S Crooke³

¹Department of Pulmonary and Critical Care Medicine, University of Minnesota School of Medicine, 640 Jackson Street, Mail Stop 11203B, MinneapolisSt. Paul, MN, 55101, USA. selic002@umn.edu.

Critical Care (London, England)

|July 5, 2022

Abstract

Background:

Chest wall loading has been shown to paradoxically improve respiratory system compliance (C_RS) in patients with moderate to severe acute respiratory distress syndrome (ARDS). The most likely, albeit unconfirmed, mechanism is relief of end-tidal overdistension in 'baby lungs' of low-capacity. The purpose of this study was to define how small changes of tidal volume (V_T) and positive end-expiratory pressure (PEEP) affect C_RS (and its associated airway pressures) in patients with ARDS who demonstrate a paradoxical response to chest wall loading. We hypothesized that small reductions of V_T or PEEP would alleviate overdistension and favorably affect C_RS and conversely, that small increases of V_T or PEEP would worsen C_RS.

Methods:

Prospective, multi-center physiologic study of seventeen patients with moderate to severe ARDS who demonstrated paradoxical responses to chest wall loading. All patients received mechanical ventilation in volume control mode and were passively ventilated. Airway pressures were measured before and after decreasing/increasing V_T by 1 ml/kg predicted body weight and decreasing/increasing PEEP by 2.5 cmH₂O.

Results:

Decreasing either V_T or PEEP improved C_RS in all patients. Driving pressure (DP) decreased by a mean of 4.9 cmH₂O (supine) and by 4.3 cmH₂O (prone) after decreasing V_T, and by a mean of 2.9 cmH₂O (supine) and 2.2 cmH₂O (prone) after decreasing PEEP. C_RS increased by a mean of 3.1 ml/cmH₂O (supine) and by 2.5 ml/cmH₂O (prone) after decreasing V_T. C_RS increased by a mean of 5.2 ml/cmH₂O (supine) and 3.6 ml/cmH₂O (prone) after decreasing PEEP (P < 0.01 for all). Small increments of either V_T or PEEP worsened C_RS in the majority of patients.

Conclusion:

Patients with a paradoxical response to chest wall loading demonstrate uniform improvement in both DP and C_RS following a reduction in either V_T or PEEP, findings in keeping with prior evidence suggesting its presence is a sign of end-tidal overdistension. The presence of 'paradox' should prompt re-evaluation of modifiable determinants of end-tidal overdistension, including V_T, PEEP, and body position.

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