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Congenital corneal anesthesia: A case series
Aruna P Jayarajan1, Ashok Sharma2, Rajan Sharma2
1Cornea and Refractive Services, Aravind Eye Hospital, Pondicherry, India.
Indian Journal of Ophthalmology
|July 6, 2022
Summary
Congenital corneal anesthesia (CCA) is a rare condition affecting the cornea. This case series highlights its varied presentations, outcomes, and the need for timely intervention, with some cases requiring corneal transplants.
Area of Science:
- Ophthalmology
- Genetics
- Pediatric Medicine
Background:
- Congenital corneal anesthesia (CCA) is an exceptionally rare condition impacting corneal sensitivity.
- It can manifest in isolation, as part of a congenital syndrome, or alongside systemic anomalies.
- Understanding CCA's diverse clinical spectrum is crucial for effective management.
Observation:
- This case series reviewed 12 eyes of patients with CCA.
- The average age of presentation was 3.2 years, with a female predominance (75%).
- Fifty percent of patients had bilateral involvement, and 50% presented with corneal ulcers.
Findings:
- Two eyes required therapeutic keratoplasty due to corneal perforation.
- Most patients presented with isolated CCA, with one case associated with hereditary sensory autonomic neuropathy.
Implications:
- Understanding the diverse clinical spectrum of CCA is crucial for timely diagnosis and management.
- This series underscores the potential for severe complications like corneal perforation and the need for surgical intervention in some cases.
Keywords:
Congenital corneal anesthesiaabsent corneal sensationhereditary and sensory autonomic neuropathy
