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Biomarkers in an Animal Model for Revealing Neural, Hematologic, and Behavioral Correlates of PTSD
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Decoding Shared Versus Divergent Transcriptomic Signatures Across Cortico-Amygdala Circuitry in PTSD and Depressive

Andrew E Jaffe1, Ran Tao1, Stephanie C Page1

  • 1Lieber Institute for Brain Development, Baltimore (Jaffe, Tao, Page, Maynard, Pattie, Nguyen, Deep-Soboslay, Bharadwaj, Shin, Hyde, Martinowich, Kleinman); Department of Neuroscience (Jaffe, Martinowich), Department of Genetic Medicine, McKusick-Nathans Institute of Genetic Medicine (Jaffe), and Department of Psychiatry and Behavioral Sciences (Jaffe, Hyde, Martinowich, Kleinman), Johns Hopkins University School of Medicine, Baltimore; Center for Computational Biology, Johns Hopkins University, Baltimore (Jaffe); Department of Biostatistics and Department of Mental Health, Johns Hopkins Bloomberg School of Public Health, Baltimore (Jaffe); Department of Psychiatry and Behavioral Sciences, Texas A&M College of Medicine, Bryan, Tex., Department of Veterans Affairs, VISN 17 Center of Excellence for Research on Returning War Veterans, Waco, Tex., Central Texas Veterans Health Care System, Temple, Tex., and Baylor Scott & White Psychiatry, Temple, Tex. (Young); Department of Psychiatry, Geisel School of Medicine at Dartmouth, Hanover, N.H. (Friedman); National Center for PTSD, U.S. Department of Veterans Affairs (Friedman); Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, N.C. (Williamson); Durham VA Health Care System, Durham, N.C. (Williamson); Department of Neurology, Johns Hopkins School of Medicine, Baltimore (Hyde).

The American Journal of Psychiatry
|July 6, 2022
PubMed
Summary

This study found shared gene expression patterns in the brain for posttraumatic stress disorder (PTSD) and major depressive disorder (MDD), highlighting immune pathways and GABAergic neurons in PTSD.

Keywords:
Depressive DisordersHuman Postmortem TissueMajor Depressive DisorderPosttraumatic Stress Disorder (PTSD)RNA Sequencing

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