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In-hospital mortality prediction using frailty scale and severity score in elderly patients with severe COVID-19

Yong Sub Na1, Jin Hyoung Kim2, Moon Seong Baek3

  • 1Department of Pulmonology and Critical Care Medicine, Chosun University Hospital, Gwangju, Korea.

Acute and Critical Care
|July 6, 2022
PubMed

Insights

The Sequential Organ Failure Assessment (SOFA) score effectively predicts in-hospital mortality in elderly patients with severe COVID-19. This score is a valuable tool for assessing prognosis in this vulnerable population.

Area of Science:

  • Gerontology
  • Infectious Diseases
  • Critical Care Medicine

Background:

  • Elderly COVID-19 patients face high disease severity and mortality.
  • Predictive value of frailty and severity scores for elderly COVID-19 mortality is unclear.
  • This study examines frailty and severity scores for predicting COVID-19 mortality in older adults.

Purpose of the Study:

  • To evaluate the utility of various clinical scores in predicting in-hospital mortality among elderly patients with severe COVID-19.
  • To compare the predictive performance of frailty scales and severity scores.

Main Methods:

  • Multicenter retrospective study of severe COVID-19 patients in South Korea (Feb 2020-Feb 2021).
  • Assessed scores included APACHE II, CURB-65, MEWS, SOFA, CFS, and CCI.
  • Receiver operating characteristic (ROC) curve analysis was used to determine predictive value.

Main Results:

  • Included 318 elderly patients; 25.5% non-survivors.
  • Non-survivors were older with more comorbidities.
  • SOFA score demonstrated the best predictive performance (AUC=0.766, P<0.001); SOFA and CFS scores were associated with mortality.

Conclusions:

  • The Sequential Organ Failure Assessment (SOFA) score is an efficient tool for predicting in-hospital mortality in elderly patients with severe COVID-19.
  • Clinical Frailty Scale (CFS) also showed association with mortality.
Abstract

Keywords:
COVID-19critical careelderlymortality

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