Porphyrin derivative-based tandem response nanochannels triggered by Zn²⁺ and NO

We describe tandem response solid nanochannels tailored with a porphyrin derivative that show Zn²⁺ and NO gating behaviors with good selectivity, stability, and reversibility. EXAFS and fluorescence experiments showed that zinc coordinated with the porphyrin derivative as the ratio of 1 : 1 with the binding constant for 3.39 × 10⁵ M^-1. These studies are beneficial for simulating the physiological functions of ion/gas in organisms and have the potential for designing complicated logic circuits and fabricating novel biosensors.