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Updated: Sep 5, 2025

Modified Experimental Conditions for Noise-Induced Hearing Loss in Mice and Assessment of Hearing Function and Outer Hair Cell Damage
Published on: February 10, 2023
[Research on the Effects of NOX-Mediated Oxidative Stress and Hearing Loss]
Meng-Jiao He1, Rong Shen1, Hai-Yan Wang1
1School of Public Health,Hangzhou Normal University Division of Health Sciences,Hangzhou 311121,China.
Abstract:
Hearing loss is one of the most common chronic developmental diseases.The available studies have demonstrated that the occurrence and development of hearing loss is closely related to oxidative damage caused by oxidative stress.Nicotinamide adenine dinucleotide phosphate oxidase (NADPH oxidase,NOX) contribute to the production of reactive oxygen and are classified into seven subtypes (NOX1,NOX2,NOX3,NOX4,NOX5,DUOX1,and DUOX2).To explore the relationship between oxidative stress and hearing loss,this paper reviews the latest research progress in the pathological mechanism of NOX-mediated oxidative stress and hearing loss.
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