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Updated: Sep 5, 2025

Multimodal 3D Printing of Phantoms to Simulate Biological Tissue
Published on: January 11, 2020
Additively manufactured test phantoms for mimicking soft tissue radiation attenuation in CBCT using Polyjet
Sepideh Hatamikia1, Gunpreet Oberoi2, Anna Zacher3
1Austrian Center for Medical Innovation and Technology (ACMIT), Wiener Neustadt, Austria; Research center for Medical Image Analysis and Artificial Intelligence (MIAAI), Department of Medicine, Faculty of Medicine and Dentistry, Danube Private University, Krems, Austria; Center for Medical Physics and Biomedical Engineering, Medical University of Vienna, Vienna, Austria.
This study developed cost-effective Cone Beam Computed Tomography (CBCT) imaging phantoms using additive manufacturing. The novel approach successfully mimics human soft-tissue radiation attenuation for improved imaging customization.
Area of Science:
- Medical Imaging
- Additive Manufacturing
- Materials Science
Background:
- Cone Beam Computed Tomography (CBCT) requires specialized imaging phantoms for accurate calibration and testing.
- Existing phantoms can be expensive and may not fully replicate the diverse radiation attenuation properties of human soft tissues.
Purpose of the Study:
- To develop and validate a cost-effective method for creating CBCT imaging phantoms.
- To utilize modified Polyjet additive manufacturing to achieve a single material that mimics a range of human soft-tissue radiation attenuation.
- To enable customized imaging phantom development.
Main Methods:
- Designed cubic lattice test phantoms with varying air:material ratios (0-70%) using 3-Matic software.
- Printed phantoms using Polyjet technology with Vero PureWhite, VeroClear, and TangoPlus materials.
- Analyzed CT values, performed non-contact profile measurements, and conducted microCT-based volumetric analysis.
Main Results:
- Printed phantoms achieved a grey value spectrum (-757 to +286 HU) equivalent to human soft tissues.
- Dimensional accuracy reached 99.07% via non-contact profile measurement.
- Volumetric accuracy ranged from 84.80% to 94.91% using microCT analysis.
- The cost for 24 test phantoms was only 83.00 Euro.
Conclusions:
- Additive manufacturing, through macrostructure manipulation, effectively modifies material radiographic visibility in CBCT.
- This technique allows for the creation of customized imaging phantoms with 1 mm³ resolution.
- The developed method offers a cost-effective solution for producing versatile CBCT phantoms.
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