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Multiple diagnostic methods for mucormycosis: A retrospective case series.

JiaXin Wang1, YaoMin Wang1, Fei Han1

  • 1Kidney Disease Center, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, China.

Journal of Clinical Laboratory Analysis
|July 6, 2022
PubMed
Summary

Early diagnosis of mucormycosis, a rare fungal infection, is vital for patient survival. Prompt identification and treatment significantly improve outcomes for this aggressive disease.

Keywords:
biopsycultureearly diagnosismetagenomic next-generation sequencing (mNGS)mucormycosis

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Area of Science:

  • Mycology
  • Infectious Diseases
  • Clinical Medicine

Background:

  • Mucormycosis is a rare but highly fatal invasive fungal infection.
  • Timely diagnosis and effective treatments are critical for improving patient survival rates.

Purpose of the Study:

  • To analyze clinical characteristics, treatment, and outcomes of mucormycosis patients.
  • To identify factors influencing prognosis in mucormycosis.

Main Methods:

  • Retrospective review of adult mucormycosis cases (2000-2021) at a single institution.
  • Data collection included demographics, clinical presentation, treatment, and outcomes.
  • Comparison with existing literature.

Main Results:

  • Eleven cases analyzed: multisite (4), skin (1), lung (5), gastrointestinal (1).
  • Diagnosis primarily relied on pathological and histological findings; metagenomic next-generation sequencing (mNGS) used in three cases.
  • Delayed diagnosis (>7 days admission or >30 days symptom onset) correlated with poorer prognosis.

Conclusions:

  • Increased awareness and reduced diagnosis time are key to improving mucormycosis prognosis.
  • Suspected cases require prompt sample collection for biopsy, culture, or mNGS for definitive diagnosis.