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Solid-phase Synthesis of [4.4] Spirocyclic Oximes
Published on: February 6, 2019
Expeditious entry into carbocyclic and heterocyclic spirooxindoles
1Sudhanva Technologies Private Limited, No. 7, Weavers Colony, Basavanapura, Bengaluru, Karnataka 560083, India. madhug.niper@gmail.com.
Abstract:
Spirocyclic frameworks have attracted synthetic practitioners due to their unique three-dimensional assembly, improved metabolic stability, solubility, and increased molecular complexity with regard to planar architectures. A recent surge in the number of spirocyclic oxindoles inhibiting enzymes, moderating unique protein-protein interactions, modulating receptors and transporters is testament to their prevalence. Against this background, the construction of spirocyclic frameworks containing an oxindole moiety as a torsional switch via stereoselective methods is in great demand. Herein we present a summary of the past three years in the progress of metal, organic molecule, nanostructured particle mediated, and even uncatalyzed versions of the highly diastereo- and enantioselective pathways leading to oxindole spirocycles.
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