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Preparation, Purification, and Characterization of Lanthanide Complexes for Use as Contrast Agents for Magnetic Resonance Imaging
Published on: July 21, 2011
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Lanthanide porphyrinoids as molecular theranostics
Guo-Qing Jin1, Calvin V Chau2, Jonathan F Arambula2,3
1Beijing National Laboratory for Molecular Sciences, College of Chemistry and Molecular Engineering, Peking University, Beijing 100871, P. R. China. zhangjunlong@pku.edu.cn.
Chemical Society Reviews
|July 6, 2022
Summary
Lanthanide porphyrinoids are emerging as versatile theranostics for disease diagnosis and therapy. Recent advances focus on optimizing these agents for fluorescence imaging, MRI, and phototherapy.
Area of Science:
- Materials Science
- Radiochemistry
- Nanomedicine
Background:
- Lanthanide (Ln) porphyrinoids are gaining traction as theranostic agents, combining diagnostic and therapeutic capabilities.
- Theranostics offer a dual approach for disease management, enabling simultaneous detection and treatment.
Purpose of the Study:
- To review the historical development and current state-of-the-art of lanthanide porphyrinoids as theranostic agents.
- To highlight recent progress in the past decade, focusing on applications and optimization strategies.
Main Methods:
- Review of applications in near-infrared (NIR) fluorescence imaging (FL) and magnetic resonance imaging (MRI).
- Discussion of their use in radiotherapy and chemotherapy.
- Analysis of phototheranostic strategies involving regulation of porphyrinic triplet energy dissipation.
Main Results:
- Lanthanide porphyrinoids show promise in various diagnostic imaging modalities and therapeutic interventions.
- Phototheranostic applications are enhanced by strategies like regioisomeric effects, metal regulation, and expanded porphyrinoids.
- Significant progress has been made in optimizing these agents over the last decade.
Conclusions:
- Lanthanide porphyrinoids represent a promising platform for advanced theranostics and phototheranostics.
- Future developments will likely focus on structure-based innovations, functional improvements, and novel biological activation methods.
