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Updated: Sep 5, 2025

Developing a Rat Model for Bipolar Disorder
Published on: May 2, 2025
Visual electrophysiology and neuropsychology in bipolar disorders: A review on current state and perspectives
Katelyne Tursini1, Steven Le Cam2, Raymund Schwan3
1INSERM U1254, Université de Lorraine, IADI, 54000 Nancy, France; BioSerenity, 20 Rue Berbier du Mets, 75013 Paris, France.
Abstract:
Bipolar disorder is a lifelong condition. Today, there is a urgent need to find indicators of the disease. Specifically, they could be useful to improve the diagnosis and the early detection, the prognosis, to estimate the treatment response and to create homogeneous subgroups of patients based on similar pathophysiological mechanisms. Here, we assume that visual electrophysiology in combination with a neuropsychological assessment can give additional data to routine practice, especially to precise specific damages and pathophysiological characteristics of these patients. Visual electrophysiology is characterized by an electroretinogram and the delivery of visual evoked potentials, which measure retinal and visual cortical neuronal functioning in response to visual stimulations. This review highlights the interest of visual electrophysiology and neuropsychology performed in isolation and to present the benefits of combining these measures. We will review the results based on these measures in patients with bipolar disorders. Finally, we argue for the use of innovative techniques such as signal processing and artificial intelligence techniques for routine care and precision medicine in bipolar disorders.
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