Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Signatures in the gut microbiome of German elite athletes: insights from a matched-subgroup analysis.

mSystems·2026
Same author

Genetic and non-genetic determinants of vitamin D status: a polygenic score analysis in elite athletes.

Frontiers in genetics·2026
Same author

Interprofessional Training in Virtual Reality for Health Care: Experimental Study on Procedural Knowledge and Willingness to Collaborate.

JMIR medical education·2026
Same author

Development of a mobile application to estimate time of death based on the compound method.

International journal of legal medicine·2026
Same author

Evaluating the forehead temperature for estimating the postmortem interval.

International journal of legal medicine·2026
Same author

Assessing the influence of CYP2C9 and CYP2C19 genotypes on the metabolism of CBD-cannabis after controlled single and repetitive consumption.

International journal of legal medicine·2026
Same journal

Technical note: Development of a UHPLC-MS/MS method for the analysis of hCG and IGF-I from dried blood spots: A preliminary study.

Forensic science international·2026
Same journal

A novel and robust deep learning model for sibling firearm matching.

Forensic science international·2026
Same journal

Changes in C-reactive protein levels over time in high-temperature environments using postmortem blood.

Forensic science international·2026
Same journal

Insights from the first synthetic cannabinoid clandestine lab dismantled in Brazil.

Forensic science international·2026
Same journal

Determination of the new psychoactive substances MDMB-4en-PINACA, ADB-BUTINACA and some of their metabolites in blood and urine using DLLE-LC-MS/MS: application to real forensic case samples.

Forensic science international·2026
Same journal

The revolver halo as a forensic marker: Raman spectroscopic evidence of primer-driven gunshot residue deposition.

Forensic science international·2026
See all related articles

Related Experiment Video

Updated: Sep 5, 2025

Measuring Post-Stroke Cerebral Edema, Infarct Zone and Blood-Brain Barrier Breakdown in a Single Set of Rodent Brain Samples
04:32

Measuring Post-Stroke Cerebral Edema, Infarct Zone and Blood-Brain Barrier Breakdown in a Single Set of Rodent Brain Samples

Published on: October 23, 2020

8.1K

Post mortem evaluation of brain edema using quantitative MRI.

Melanie Bauer1, Celine Berger1, Kathrin Gerlach1

  • 1Institute of Forensic Medicine, Department of Biomedical Engineering, University of Basel, Basel, Switzerland; Institute of Forensic Medicine, Health Department Basel-Stadt, Basel, Switzerland.

Forensic Science International
|July 6, 2022
PubMed
Summary
This summary is machine-generated.

Post mortem MRI offers an objective method to detect brain edema. Quantitative MRI parameters T2 and fractional anisotropy (FA) in the cortex accurately differentiate between edematous and non-edematous brains.

Keywords:
Brain edemaForensic medicineNormalized cerebral weightPost mortem magnetic resonance imagingQuantitative MRI

More Related Videos

In Vivo Tracking of Edema Development and Microvascular Pathology in a Model of Experimental Cerebral Malaria Using Magnetic Resonance Imaging
09:04

In Vivo Tracking of Edema Development and Microvascular Pathology in a Model of Experimental Cerebral Malaria Using Magnetic Resonance Imaging

Published on: June 8, 2017

6.6K
Quantification of Neurovascular Protection Following Repetitive Hypoxic Preconditioning and Transient Middle Cerebral Artery Occlusion in Mice
09:48

Quantification of Neurovascular Protection Following Repetitive Hypoxic Preconditioning and Transient Middle Cerebral Artery Occlusion in Mice

Published on: May 4, 2015

13.9K

Related Experiment Videos

Last Updated: Sep 5, 2025

Measuring Post-Stroke Cerebral Edema, Infarct Zone and Blood-Brain Barrier Breakdown in a Single Set of Rodent Brain Samples
04:32

Measuring Post-Stroke Cerebral Edema, Infarct Zone and Blood-Brain Barrier Breakdown in a Single Set of Rodent Brain Samples

Published on: October 23, 2020

8.1K
In Vivo Tracking of Edema Development and Microvascular Pathology in a Model of Experimental Cerebral Malaria Using Magnetic Resonance Imaging
09:04

In Vivo Tracking of Edema Development and Microvascular Pathology in a Model of Experimental Cerebral Malaria Using Magnetic Resonance Imaging

Published on: June 8, 2017

6.6K
Quantification of Neurovascular Protection Following Repetitive Hypoxic Preconditioning and Transient Middle Cerebral Artery Occlusion in Mice
09:48

Quantification of Neurovascular Protection Following Repetitive Hypoxic Preconditioning and Transient Middle Cerebral Artery Occlusion in Mice

Published on: May 4, 2015

13.9K

Area of Science:

  • Forensic pathology
  • Neuroimaging
  • Medical diagnostics

Background:

  • Autopsy relies on macroscopic signs for brain edema assessment.
  • Objective, noninvasive, and quantitative methods are needed for post mortem brain edema evaluation.

Purpose of the Study:

  • To assess the suitability of magnetic resonance imaging (MRI) for differentiating edematous from nonedematous brains post mortem.
  • To explore quantitative MRI parameters as objective indicators of brain edema.

Main Methods:

  • Post mortem in situ MRI was performed on 22 deceased individuals prior to autopsy.
  • Quantitative MRI parameters (T1, T2, T2*, FA, mean diffusivity) were computed for different brain regions.
  • Normalized cerebral weight (NCW) was calculated and correlated with MRI parameters using linear regression.

Main Results:

  • Significant correlations were found between T2 and fractional anisotropy (FA) with NCW in the cortex.
  • These MRI parameters demonstrated the best fit in linear regression models for edema assessment.
  • Quantitative MRI provides objective data on brain edema status.

Conclusions:

  • Quantitative MRI, specifically T2 and FA in the cortex, is effective in differentiating edematous from nonedematous brains.
  • Post mortem in situ MRI can provide valuable, objective information on brain edema before or in lieu of autopsy.