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Related Experiment Videos

Bowel flora changes in humans receiving cefixime (CL 284,635) or cefaclor.

S M Finegold, L Ingram-Drake, R Gee

    Antimicrobial Agents and Chemotherapy
    |March 1, 1987
    PubMed
    Summary
    This summary is machine-generated.

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    Cefixime and cefaclor alter fecal flora differently. Cefixime impacts indigenous bacteria, while cefaclor promotes new bacterial growth, with both showing potential for opportunistic pathogen emergence.

    Area of Science:

    • Microbiology
    • Pharmacology
    • Gastroenterology

    Background:

    • Oral cephalosporins are widely used antibiotics.
    • Understanding their impact on the gut microbiome is crucial for patient health.
    • Fecal flora alterations can lead to dysbiosis and secondary infections.

    Purpose of the Study:

    • To compare the effects of cefixime and cefaclor on the fecal flora in healthy young males.
    • To investigate the specific changes in bacterial populations induced by each antibiotic.
    • To assess the potential for opportunistic pathogen overgrowth.

    Main Methods:

    • A comparative study involving twelve healthy young male subjects.
    • Administration of cefixime (400 mg daily) or cefaclor (250 mg TID) for two weeks.

    Related Experiment Videos

  • Analysis of fecal flora composition and changes in bacterial counts.

    • Main Results:

    • Cefixime significantly decreased Escherichia coli counts and impacted indigenous flora, with some subjects showing increases in Group D streptococci and emergence of Clostridium difficile and Staphylococcus aureus.
    • Cefaclor did not decrease E. coli counts but led to the ingrowth of new flora, including new strains of Enterobacteriaceae, S. aureus, and C. difficile.
    • Both antibiotics induced modest but distinct changes in fecal microbiota composition.

    Conclusions:

    • Cefixime and cefaclor exert differential effects on the gut microbiome.
    • Cefixime's impact is more pronounced on existing bacteria, whereas cefaclor promotes colonization by new bacterial strains.
    • Both antibiotics warrant careful consideration due to their potential to disrupt the gut ecosystem and facilitate pathogen emergence.