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Updated: Sep 5, 2025
Severe Burn Injury in a Swine Model for Clinical Dressing Assessment
Published on: November 6, 2018
Hydrogel-based dressings in the treatment of partial thickness experimentally induced burn wounds in rats
Milton Junior Cândido Bernardes1, Randys Caldeira Gonçalves1, Carolyna de Sousa Carvalho2
1PhD. Universidade Federal de Goiás - Tropical Pathology and Public Health Institute - Postgraduation Program in HostParasite Relationship - Goiânia (GO), Brazil.
Purpose:
To compare four commercially available hydrogel formulations in the healing of partial thickness burns experimentally induced in rats.
Methods:
Wistar rats were used, and after the burn wound induction they were divided into the following treatment groups: G1) NaCl 0.9%; G2) 1% silver sulfadiazine; G3) Debrigel™; G4) Safgel™; G5) Dersani™; G6) Solosite™. The animals were followed during seven, 14 and 30 days after the injury induction. Morphometric, macroscopic and microscopic evaluations were performed.
Results:
The treatment with Dersani™ induced better results during the inflammatory and proliferative phases of the healing process (p<0.05). The animals treated with Safgel™ presented better scaring in the remodeling phase (p<0.05), and the treatment with Dersani™ and Solosite™ induced greater wound closure (p<0.05).
Conclusions:
The hydrogel-based dressings presented beneficial outcomes in the healing of burn wounds experimentally induced in rats due to their ability in maintain the humidity of the wound, in removing the exudate, in promoting cell migration and collagen production during the different phases of the healing process.
