A practical method to improve the performance of knowledge-based VMAT planning for endometrial and cervical cancer

The aim of this work was to demonstrate a practical and effective method to improve the performance of RapidPlan (RP) model.

203 consecutive clinical VMAT plans (P₀) for cervical and endometrial cancer were used to train an RP model (M₀). The plans were then reoptimized by M₀ to generate 203 new plans (P₁). Compared with P₀, 150 plans with a lower mean dose (MD) of bladder, rectum and PBM were selected from P₁ to configure a new RP model (M₁). A final RP model (M₂) was trained using plans in M₁ and the remaining 53 plans from P₁ (excluding OARs with worse MD) and the corresponding plans from P₀ (only including OARs with better MD). The models were validated on the mentioned 53 plans (closed-loop set) and 46 patient cohorts outside the training library (open-loop set). p < 0.05 was considered statistically significant.

For closed-loop validation, the difference of D_2%, D_98% and CI_95% between groups was of no statistical significance, the homogeneity index (HI) was lower in the groups of RP models (p < 0.05). The MD of all OARs decreased monotonically in the sequence of the clinical group, group M₀, M₁ and M₂, except the MD of bowel in M₁ and MD of LFH in M₂. Similarly, for open-loop validation, there was no significant difference in D_2%, D_98% and HI between groups, but CI_95% was larger in the clinical group (p < 0.05). The MD of all OARs decreased monotonically in the sequence of the clinical group, group M₀, M₁ and M₂, with the exception of bowel in M₁.

The practical method of incorporating plan data of better-sparing OARs from both the clinical VMAT plans and the re-optimized plans could further improve the performance of the RP model.