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Correlation between tuberculosis-specific interferon-γ release assay and intrathoracic calcification: A
Izumi Yamatani1, Kosaku Komiya1, Hisayuki Shuto1
1Respiratory Medicine and Infectious Diseases, Oita University Faculty of Medicine, Yufu, Oita, Japan.
Mediastinal lymph node calcification on chest CT, with or without lung calcification, is linked to positive interferon-γ release assay (IGRA) results, suggesting past tuberculosis infection.
Area of Science:
- Radiology and Imaging
- Infectious Diseases
- Pulmonology
Background:
- Tuberculosis (TB) infection can cause lung calcification.
- The link between intrathoracic calcification and interferon-γ release assay (IGRA) results requires further clarification.
Purpose of the Study:
- To investigate the association between intrathoracic calcification and IGRA results in patients without active TB.
Main Methods:
- Retrospective analysis of patients who underwent chest X-ray, chest CT, and IGRA.
- Exclusion of patients with active TB or TB treatment history.
- Binomial logistic regression used to analyze calcification and IGRA results.
Main Results:
- 38% of 574 patients had positive IGRA results.
- Positive IGRA results were associated with older age, comorbidities, and TB exposure history.
- Mediastinal lymph node calcification on CT, with or without lung calcification, was independently associated with positive IGRA results.
Conclusions:
- Mediastinal lymph node calcification on chest CT is a significant indicator of positive IGRA results, independent of TB exposure.
- The presence of calcified mediastinal lymph nodes on CT may suggest previous or latent tuberculosis infection.
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