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Neurons contribute to pathology in a mouse model of Krabbe disease in a cell-autonomous manner
Pedro Brites1, Monica M Sousa2
1Neurolipid Biology Group, Instituto de Biologia Molecular e Celular (IBMC), Instituto de Investigação e Inovação em Saúde (i3S), University of Porto, Porto, Portugal.
Plos Biology
|July 6, 2022
Abstract:
In this issue of PLOS Biology, Kreher and colleagues show in a mouse model that in vivo, neurons and not only myelinating glia are primary effectors of disease progression in Krabbe disease. The neuron-specific model generated allows the unprecedented capacity to investigate the neuronal autonomous component of this disorder.
