Related Experiment Video
Updated: Sep 5, 2025

Generation of a Mouse Spontaneous Autoimmune Thyroiditis Model
Published on: March 17, 2023
IgG4-positive Hashimoto thyroiditis and its association with IgG4-related sclerosing disease
Aagat Sharma Khatiwada1, Natasha Choudhury2
1Department of Otolaryngology, East Surrey Hospital, Redhill, Surrey, UK aagat.sharmakhat@nhs.net.
Abstract:
A woman in her 50s was referred with suspected thyroid malignancy and underwent total thyroidectomy. Immunohistochemical analysis revealed IgG4-positive Hashimoto's thyroiditis. IgG4-related thyroid disease is poorly understood, and thought to encompass various entities including IgG4-positive Hashimoto's thyroiditis, Fibrosing Variant of Hashimoto's thyroiditis, Reidel's thyroiditis and Graves' disease with elevated IgG4 levels. Furthermore, it may be associated with a systemic fibrosing condition called 'IgG4-related sclerosing disease'. The clinical significance of IgG4-positive thyroid disease, however, remains unclear.
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