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Clinical features and recurrence of Corynebacterium kroppenstedtii infection in patients with mastitis

Weiwei Zeng1,2, Sixian Lao3,4, Wenbin Jia2

  • 1The Second People's Hospital of Longgang District, Shenzhen, 518112, China.

BMC Women'S Health
|July 6, 2022
PubMed
Abstract

Insights

Corynebacterium kroppenstedtii mastitis presents with more pus in non-granulomatous lobular mastitis and higher CRP in granulomatous lobular mastitis. A combination of cefuroxime and triamcinolone acetonide lavage may reduce recurrence.

Area of Science:

  • Infectious Diseases
  • Bacteriology
  • Clinical Medicine

Background:

  • Limited research exists on clinical distinctions in mastitis caused by Corynebacterium kroppenstedtii.
  • Previous studies primarily focused on antimicrobial susceptibility, detection, and treatment of C. kroppenstedtii infections.

Purpose of the Study:

  • To investigate and compare the clinical features of mastitis patients infected with C. kroppenstedtii.
  • To analyze demographic and laboratory data differentiating mastitis types.
  • To evaluate the efficacy of treatments in reducing C. kroppenstedtii mastitis recurrence.

Main Methods:

  • Retrospective analysis of 133 patients with C. kroppenstedtii mastitis (August 2016 - September 2019).
  • Identification of C. kroppenstedtii using mass spectrometry.
  • Comparison of demographics, clinical diagnoses, laboratory results, and treatment outcomes.

Main Results:

  • Pus incidence was higher in non-granulomatous lobular mastitis (NGLM) (56.6%) versus granulomatous lobular mastitis (GLM) (33.3%).
  • C-reactive protein (CRP) levels were elevated in GLM (12.50 mg/L) compared to NGLM (6.05 mg/L).
  • Treatment with cefuroxime and triamcinolone acetonide lavage resulted in a 25.9% recurrence rate.

Conclusions:

  • Elevated pus, large masses, and high CRP may indicate C. kroppenstedtii infection in mastitis.
  • These clinical indicators can aid in determining bacterial infection presence.
  • Combined antibiotic (cefuroxime) and triamcinolone acetonide lavage therapy can potentially decrease mastitis recurrence.
Keywords:
AntibioticsClinical featuresCorynebacterium kroppenstedtiiGranulomatous lobular mastitisTreatment

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