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Related Concept Videos

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Primary Lymphoid Organs

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Primary lymphoid organs are pivotal in the formation, development, and maturation of lymphocytes, the white blood cells that serve as the backbone of our immune system. This crucial function underscores their fundamental role in maintaining our overall health and immunity. The two primary lymphoid organs of prime importance are the red bone marrow and the thymus.
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Secondary organs, including lymph nodes, the spleen, and mucosa-associated lymphoid tissue (MALT), work harmoniously to protect us from disease and infection.
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Updated: Sep 5, 2025

Author Spotlight: Exploring Orofacial Muscle Regeneration – Insights and Innovations
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Orofacial intramuscular lymphoma: first presentation.

Lucas T Duong1,2,3,4, Marie Rollin1,3, François Bidault5,6

  • 1Health Faculty, Université Paris Cité, France, Île-de-France, France.

Ear, Nose, & Throat Journal
|July 7, 2022
PubMed
Summary
This summary is machine-generated.

A rare skeletal muscle diffuse large B-cell lymphoma (DLBCL) presented as a cheek mass. This case highlights the importance of considering DLBCL in oral cavity soft tissue tumors.

Keywords:
B-cell lymphomaPET-scanchemotherapylymphomamagnetic resonance imagingskeletal muscle

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Area of Science:

  • Oncology
  • Pathology

Background:

  • Lymphoma encompasses diverse clinical entities, with diffuse large B-cell lymphomas (DLBCL) being a significant subtype.
  • Skeletal muscle lymphomas are rare, accounting for less than 2% of B-cell lymphomas, and are exceptionally uncommon in the orofacial region.

Purpose of the Study:

  • To report a rare case of skeletal muscle diffuse large B-cell lymphoma in the orofacial area.
  • To emphasize the diagnostic challenges and considerations for soft tissue tumors in the oral cavity.

Main Methods:

  • A case study of a 34-year-old male presenting with a painless growing cheek mass.
  • Diagnostic imaging included Magnetic Resonance Imaging (MRI) of the mandible and whole-body 18F-FDG PET/CT.
  • Diagnosis was confirmed via intraoral biopsy.

Main Results:

  • MRI revealed a large, well-defined mass involving the mandible, buccal floor, and subcutaneous tissues.
  • PET/CT showed intense, isolated hypermetabolism consistent with tumoral permeation.
  • The patient achieved complete remission after four cycles of chemotherapy, with no recurrence at one year.

Conclusions:

  • Skeletal muscle diffuse large B-cell lymphoma can present atypically in the orofacial region, mimicking other conditions like chronic cellulitis.
  • This rare entity should be included in the differential diagnosis of orofacial soft tissue tumors.
  • Prompt diagnosis and appropriate chemotherapy can lead to favorable outcomes.