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Refractory Mycoplasma Pneumonia in Children: A Systematic Review and Meta-analysis of Laboratory Features and

Wanjie Huang1, Xianhong Xu1, Wenqi Zhao1

  • 1Department of Pediatrics, Shengjing Hospital of China Medical University, Shenyang, Liaoning, China.

Journal of Immunology Research
|July 7, 2022
PubMed
Abstract

Insights

Refractory Mycoplasma pneumoniae pneumonia (RMPP) in children can be predicted by elevated C-reactive protein (CRP), lactate dehydrogenase (LDH), neutrophils, and lung consolidation. Early identification of these biomarkers aids in timely RMPP treatment.

Area of Science:

  • Pediatrics
  • Infectious Diseases
  • Pulmonology

Background:

  • Mycoplasma pneumoniae is a frequent cause of community-acquired pneumonia (CAP) in children.
  • While typically self-limiting, M. pneumoniae infections can progress to refractory pneumonia (RMPP).
  • Early identification of RMPP is crucial for effective treatment.

Purpose of the Study:

  • To analyze clinical characteristics of C-reactive protein (CRP), lactate dehydrogenase (LDH), erythrocyte sedimentation rate (ESR), D-dimer, neutrophils, lymphocytes, and lung consolidation in RMPP.
  • To explore the predictive value of these markers in the early stages of RMPP.

Main Methods:

  • A systematic literature search was conducted across multiple databases (PubMed, Embase, Web of Science, etc.) up to February 23, 2021.
  • Meta-analysis was performed using mean difference (MD) with 95% confidence intervals (CI) for continuous variables.
  • Odds ratios (OR) with 95% CI were used to evaluate the correlation between lung consolidation and RMPP.

Main Results:

  • Elevated CRP, LDH, neutrophils, and increased risk of lung consolidation were observed in RMPP patients compared to non-RMPP cases.
  • D-dimer showed a non-significant trend towards elevation in RMPP.
  • No significant differences in ESR or lymphocyte percentages were found between RMPP and non-RMPP groups.

Conclusions:

  • CRP, LDH, neutrophils, and lung consolidation are identified as significant predictive factors for RMPP in children.
  • These biomarkers can aid in the early diagnosis and management of refractory Mycoplasma pneumoniae pneumonia.

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