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Cost-Effectiveness Analysis of Rivaroxaban in Chinese Patients With Stable Cardiovascular Disease

Tianyu Feng1, Zhou Zheng1, Shang Gao1

  • 1School of Public Health, Jilin University, Changchun, China.

Frontiers in Pharmacology
|July 7, 2022
PubMed

Insights

Low-dose rivaroxaban plus aspirin is a cost-effective strategy for secondary prevention in stable cardiovascular disease patients in China. This combination therapy offers improved health outcomes at an acceptable cost compared to aspirin alone.

Area of Science:

  • Cardiovascular Medicine
  • Health Economics

Background:

  • Stable cardiovascular diseases (CVD) require effective secondary prevention strategies.
  • Evaluating the economic value of novel therapeutic combinations is crucial for healthcare resource allocation.

Purpose of the Study:

  • To assess the cost-effectiveness of low-dose rivaroxaban plus aspirin versus aspirin alone for secondary prevention in Chinese patients with stable CVD.
  • To compare the cost-effectiveness of rivaroxaban alone against aspirin alone.

Main Methods:

  • A Markov model was developed using TreeAge 2019 to evaluate costs and quality-adjusted life years (QALYs).
  • Transitional probabilities were sourced from the COMPASS trial; costs and utilities were derived from Chinese data.
  • The Incremental Cost-Effectiveness Ratio (ICER) was calculated, using a willingness-to-pay threshold of US$11,000.

Main Results:

  • Low-dose rivaroxaban plus aspirin yielded an ICER of US$7937.30 per QALY gained compared to aspirin alone.
  • Rivaroxaban alone showed an ICER of US$15,045.78 per QALY gained versus aspirin alone.
  • Both strategies were evaluated against the established willingness-to-pay threshold.

Conclusions:

  • Low-dose rivaroxaban combined with aspirin appears to be a cost-effective option for secondary prevention in stable cardiovascular disease patients in China.
  • The findings support the adoption of this combination therapy within the Chinese healthcare system.

Keywords:
COMPASSaspirincost-effectivenessmarkov modelrivaroxaban

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