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Related Experiment Videos

Lymphocyte function and abdominal operations. Trauma vs elective surgery.

D V Feliciano, R B O'Gorman, C G Bitondo

    Archives of Surgery (Chicago, Ill. : 1960)
    |June 1, 1987
    PubMed
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    Abdominal trauma significantly depresses in vitro lymphocyte transformation, a key immune response. This immune alteration was not observed after elective abdominal surgery, highlighting trauma

    Area of Science:

    • Immunology
    • Surgical Research
    • Trauma Medicine

    Background:

    • Phytohemagglutinin-induced lymphocyte transformation is a measure of cellular immune function.
    • Abdominal trauma can impact systemic physiological responses, including immune function.

    Purpose of the Study:

    • To investigate alterations in in vitro lymphocyte transformation following abdominal trauma.
    • To compare immune response in trauma patients versus those undergoing elective abdominal surgery.

    Main Methods:

    • Measured lymphocyte transformation via tritiated thymidine incorporation in 30 trauma patients and 20 elective surgery patients.
    • Determined lymphocyte response by the concentration required for half-maximal radioactive label incorporation.
    • Utilized a constant amount of phytohemagglutinin and a standard incubation period.

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    Main Results:

    • Lymphocyte transformation was markedly depressed in patients following abdominal trauma and surgery.
    • No significant alteration in lymphocyte response was observed in patients who underwent elective abdominal surgery.

    Conclusions:

    • Abdominal trauma leads to a significant depression of in vitro lymphocyte transformation.
    • Elective abdominal surgery does not appear to alter this specific measure of immune function.
    • Findings suggest a distinct immunomodulatory effect of traumatic injury compared to elective surgery.