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TNF-α (G308A) Polymorphism and Vascular Parkinson Complicated with Pulmonary Infection

Xiaoyun Sun1, Yuping He1, Zhuoping Shen2

  • 1Department of Neurology, Zhuji People's Hospital, Zhejiang Province, China.

Journal of the College of Physicians and Surgeons--Pakistan : JCPSP
|July 7, 2022
PubMed
Abstract

Insights

Tumor necrosis factor-α (TNF-α) G308A polymorphism is linked to Vascular Parkinson (VP) with pulmonary infections. Patients with VP and the TNF-α G308A AA genotype or A allele face a higher risk of infection.

Area of Science:

  • Genetics
  • Neurology
  • Infectious Diseases

Background:

  • Tumor necrosis factor-α (TNF-α) plays a role in inflammation and immune responses.
  • Vascular Parkinson (VP) is a neurodegenerative disorder often complicated by infections.
  • The G308A polymorphism in the TNF-α gene may influence susceptibility to certain conditions.

Purpose of the Study:

  • To investigate the association between the TNF-α (G308A) polymorphism and the occurrence of pulmonary infections in patients with Vascular Parkinson (VP).
  • To compare TNF-α G308A genotype and allele frequencies, as well as serum TNF-α levels, between VP patients with and without pulmonary infections.

Main Methods:

  • An analytical study was conducted involving 170 patients: 85 with VP complicated by pulmonary infection (observation group) and 85 with VP (control group).
  • Genotyping of the TNF-α (G308A) polymorphism and measurement of serum TNF-α levels were performed for all participants.
  • Hardy-Weinberg equilibrium was tested for genotype distributions.

Main Results:

  • Genotype distribution and allele frequencies of TNF-α (G308A) differed significantly between the observation and control groups (p <0.001).
  • Serum TNF-α levels were significantly higher in the observation group compared to the control group (p <0.001).
  • Within the observation group, patients with the GA+AA genotype (carrying the A allele) exhibited higher serum TNF-α levels than those with the GG genotype (p <0.001).

Conclusions:

  • The TNF-α (G308A) polymorphism is significantly associated with Vascular Parkinson (VP) complicated by pulmonary infection.
  • VP patients carrying the TNF-α (G308A) AA genotype or the A allele demonstrate an elevated risk for developing pulmonary infections.

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