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Photocatalytic glucose-appended bio-compatible Ir(III) anticancer complexes
Zilin Zhu1, Li Wei1, Yidan Lai2
1School of Pharmaceutical Sciences (Shenzhen), Shenzhen Campus of Sun Yat-sen University, Sun Yat-sen University, Shenzhen 518107, P. R. China. huanghy87@mail.sysu.edu.cn.
Dalton Transactions (Cambridge, England : 2003)
|July 7, 2022
Abstract:
Rationally-designed glucose-appended Ir(III) photo-catalysts ([Ir(N,C)2(N,N-Glc)]+, Ir1-Ir3) show visible light-induced catalytic NAD(P)H oxidation in aqueous solution. The highly in vivo biocompatible complex, Ir3, shows lysosome and mitochondria targeting necro-apoptotic photo-cytotoxicity against various cancer cell lines and multicellular spheroids, while remaining non-toxic in the dark.

