Ascorbate-assisted nitric oxide release from photocontrollable nitrosonium ion releasers for potent ex vivo
Naoya Ieda1, Yuka Yoshikawa1, Natsumi Tomita1
1Graduate School of Pharmaceutical Sciences, Nagoya City University, 3-1, Tanabe-dori, Mizuho-ku, Nagoya, Aichi, 467-8603, Japan. ieda@phar.nagoya-cu.ac.jp.
Chemical Communications (Cambridge, England)
|July 7, 2022
Abstract:
We found that N-nitrosoaminoanisole derivatives tethered to dyes work as photocontrollable nitrosonium cation releasers and are converted to potent nitric oxide releasers in the presence of sodium ascorbate. The N-nitrosoaminoanisole derivative 2 worked as a more potent photovasodilating reagent ex vivo than previously reported nitric oxide releasers.
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