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Updated: Aug 12, 2026

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Published on: June 7, 2018
Detecting subclinical anthracycline therapy-related cardiac dysfunction in patients attending Uganda Cancer Institute
Wanzhu Zhang1,2,3, Feriel Azibani4, Elena Libhaber1,5
1Cape Heart Institute, Department of Medicine & Cardiology, Faculty of Health Science, University of Cape Town, Cape Town, 7700, South Africa.
Abstract:
Aims: To investigate the incidence of anthracycline therapy-related cardiac dysfunction (ATRCD) and its predictors among Ugandan cancer patients. Patients & methods: The study recruited 207 cancer patients who were followed for 6 months after ending anthracycline therapy. Global longitudinal strain and troponin-I were the diagnostic tools. Results & conclusions: The cumulative incidences of subclinical and clinical ATRCD were 35.0 and 8.8% respectively. The predictors of clinical ATRCD were HIV infection (hazard ratio [HR]: 3.04; 95% CI: 1.26-7.32; p = 0.013), lower baseline global longitudinal strain (HR: 0.61; 95% CI: 0.53-0.71; p < 0.001) and development of subclinical ATRCD at the end of anthracycline therapy (HR: 6.61; 95% CI: 2.60-16.82; p < 0.001). Cardiac surveillance at baseline and at ending of anthracycline therapy is essential to identify high-risk patients.
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