Related Experiment Video
Updated: Sep 5, 2025

Preparation of Naringenin Solution for In Vivo Application
Published on: August 10, 2021
Effect of Citrus Flavanones on Diabetes: A Systematic Review
Sameen Azhar1, Ribka Sabahat1, Rameen Sajjad1
1Department of Diet and Nutritional Sciences, Faculty of Allied Health Sciences, University of Lahore, Lahore, Pakistan.
Background:
Fruits and vegetables play a significant role in the health and nutrition of human beings. Flavanones being the major class of flavonoids are the main phytochemicals in citrus fruits having several favorable effects, particularly in preventing diabetes.
Objective:
The purpose of this systematic review was to discuss the anti-diabetic potential of citrus flavanones based on in vivo studies.
Methods:
A search of Google Scholar, PubMed, NCBI, Research Gate, Science Direct, HEC Digital Library databases for articles that have been published since 2010 was conducted using the keywords citrus, flavanones, and diabetes.
Results:
A total of 10 articles were identified, in which it was reported that 5 flavanones have antidiabetic effects. These flavanones have many benefits, such as they help in glycemic control, regulate the biomarkers of lipid profile, renal function, and modulate the signaling pathways that increase insulin sensitivity and uptake of glucose, thus are responsible for preventing diabetes and complications related to it.
Conclusion:
Therefore, citrus flavanones are the candidates having promising anti-diabetic potential but their effect needs to be verified through human studies.
More Related Videos
Related Concept Videos
Pathophysiology of Diabetes
Type 1 diabetes is characterized by autoimmune-mediated destruction of pancreatic β cells, with environmental factors potentially triggering this process in genetically susceptible individuals. Despite many not having a family history, certain genes increase susceptibility,...
Oral Hypoglycemic Agents: Biguanides and Glitazones
Diabetes Mellitus: Type 2 and Gestational
Diabetes: Management and Pharmacotherapy
Insulin remains the cornerstone of treatment for most patients with type 1 and many...
Cancer Prevention
Some...
Diabetes Mellitus: Overview and Type I Subtype
Type 1 diabetes is an autoimmune disease in which the immune system mistakenly attacks and destroys the insulin-producing beta cells in the pancreas. As a result, the body is unable to produce sufficient insulin, and individuals with...

