Progress and application of epitranscriptomic m⁶A modification in gastric cancer

Area of Science:

• Epitranscriptomics
• Cancer Biology
• Molecular Oncology

Background:

• N6-methyladenosine (m6A) is the most prevalent epitranscriptomic modification in mammals.
• m6A plays a significant role in various physiological processes, including cancer development.
• Gastric cancer (GC) incidence and mortality rates are increasing globally, highlighting the need for novel therapeutic strategies.

Purpose of the Study:

• To review the mechanisms of RNA m6A modification.
• To elucidate the functions of m6A regulators in gastric cancer.
• To explore the crosstalk between m6A, mRNA, and noncoding RNA in GC pathogenesis.

Main Methods:

• Literature review of epitranscriptomics and gastric cancer.
• Analysis of m6A modification mechanisms and regulator functions.
• Investigation of molecular interactions involving m6A in GC.

Main Results:

• m6A modification is implicated in multiple stages of gastric carcinogenesis.
• Specific m6A regulators exhibit distinct roles in GC progression.
• Functional crosstalk between m6A, mRNA, and noncoding RNAs influences GC phenotypes.

Conclusions:

• m6A-based epitranscriptomic alterations are integral to gastric cancer.
• Targeting m6A pathways presents promising opportunities for GC diagnosis and therapy.
• Further research into m6A mechanisms could lead to improved clinical outcomes for GC patients.