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Spatially bivariate EEG-neurofeedback can manipulate interhemispheric inhibition
Masaaki Hayashi1, Kohei Okuyama2, Nobuaki Mizuguchi3
1Graduate School of Science and Technology, Keio University, Kanagawa, Japan.
Elife
|July 7, 2022
Summary
Individuals can learn to control brain sensorimotor activity using electroencephalography (EEG)-neurofeedback. This technique modulates interhemispheric inhibition (IHI), offering potential new treatments for neurological conditions.
Area of Science:
- Neuroscience
- Cognitive Science
- Biomedical Engineering
Background:
- Human behavior relies on sensorimotor brain region communication.
- Volitional control of interhemispheric sensorimotor activity is debated.
- Existing neuromodulation tools have limitations in dynamic range and control.
Purpose of the Study:
- To investigate volitional control of bilateral sensorimotor activity using a novel neurofeedback method.
- To assess the capacity for up- and down-regulating hemispheric excitability.
- To explore the modulation of interhemispheric inhibition (IHI).
Main Methods:
- Utilized spatially bivariate electroencephalography (EEG)-neurofeedback.
- Participants imagined hand movements to modulate sensorimotor activity.
- Assessed interhemispheric inhibition (IHI) using paired-pulse transcranial magnetic stimulation (TMS).
Main Results:
- Participants successfully learned to up- and down-regulate ipsilateral sensorimotor excitability.
- This modulation altered interhemispheric inhibition (IHI) magnitude.
- EEG and TMS revealed altered interhemispheric connectivity and bilateral cortical oscillations.
Conclusions:
- Spatially bivariate EEG-neurofeedback enables volitional modulation of sensorimotor activity and IHI.
- This demonstrates a powerful neuromodulation approach.
- Potential applications include stroke rehabilitation and other neurological disorders.
