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Applications of artificial intelligence multiomics in precision oncology
1CSIR-Centre for Cellular and Molecular Biology, Hyderabad, India. amitruby1@gmail.com.
Abstract:
Cancer is the second leading worldwide disease that depends on oncogenic mutations and non-mutated genes for survival. Recent advancements in next-generation sequencing (NGS) have transformed the health care sector with big data and machine learning (ML) approaches. NGS data are able to detect the abnormalities and mutations in the oncogenes. These multi-omics analyses are used for risk prediction, early diagnosis, accurate prognosis, and identification of biomarkers in cancer patients. The availability of these cancer data and their analysis may provide insights into the biology of the disease, which can be used for the personalized treatment of cancer patients. Bioinformatics tools are delivering this promise by managing, integrating, and analyzing these complex datasets. The clinical outcomes of cancer patients are improved by the use of various innovative methods implicated particularly for diagnosis and therapeutics. ML-based artificial intelligence (AI) applications are solving these issues to a great extent. AI techniques are used to update the patients on a personalized basis about their treatment procedures, progress, recovery, therapies used, dietary changes in lifestyles patterns along with the survival summary of previously recovered cancer patients. In this way, the patients are becoming more aware of their diseases and the entire clinical treatment procedures. Though the technology has its own advantages and disadvantages, we hope that the day is not so far when AI techniques will provide personalized treatment to cancer patients tailored to their needs in much quicker ways.
Insights
Next-generation sequencing (NGS) and machine learning (ML) analyze cancer data for better diagnosis and personalized treatments. AI applications are advancing cancer care by providing tailored patient information and improving clinical outcomes.
Area of Science:
- Oncology
- Bioinformatics
- Computational Biology
Background:
- Cancer is a leading global disease driven by genetic mutations.
- Next-generation sequencing (NGS) generates vast amounts of data crucial for understanding cancer.
- Machine learning (ML) and artificial intelligence (AI) offer powerful tools for analyzing complex biological data.
Purpose of the Study:
- To explore the application of NGS and ML/AI in cancer research and clinical practice.
- To highlight the role of bioinformatics in managing and analyzing multi-omics cancer data.
- To discuss the potential of AI in personalizing cancer diagnosis, prognosis, and treatment.
Main Methods:
- Utilizing multi-omics analyses from NGS data.
- Employing bioinformatics tools for data management and integration.
- Applying ML-based AI techniques for patient-specific insights.
Main Results:
- NGS data facilitate the detection of oncogenic mutations and abnormalities.
- AI applications enhance risk prediction, early diagnosis, and prognosis.
- Personalized patient information regarding treatment, progress, and lifestyle is improved.
Conclusions:
- Bioinformatics and AI are transforming cancer care by enabling personalized treatment strategies.
- These technologies provide deeper insights into cancer biology, leading to improved patient outcomes.
- The integration of AI promises faster and more tailored cancer therapies in the future.
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