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Updated: Sep 5, 2025
OP-IVM: Combining In vitro Maturation after Oocyte Retrieval with Gynecological Surgery
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Development of children born after in vitro maturation with a prematuration step versus natural conception: a
Duy L Nguyen1, Nghia A Nguyen1,2, Toan D Pham1
1HOPE Research Center, My Duc Hospital, Ho Chi Minh City, Vietnam.
Insights
Capacitation-in vitro maturation (CAPA-IVM) did not significantly impact childhood development. Children born after CAPA-IVM showed comparable developmental outcomes to those conceived naturally.
Area of Science:
- Reproductive Medicine
- Pediatric Development
- In Vitro Maturation
Background:
- Capacitation-in vitro maturation (CAPA-IVM) enhances oocyte developmental competence and embryo quality.
- No previous studies have reported on the developmental outcomes of infants born following CAPA-IVM procedures.
Purpose of the Study:
- To investigate and compare the developmental outcomes in children born after CAPA-IVM versus those conceived naturally.
- To assess the impact of CAPA-IVM on childhood physical and mental development.
Main Methods:
- A prospective cohort study was conducted involving children born via CAPA-IVM and naturally conceived children.
- Propensity score matching was used to create comparable groups.
- Parents completed the Developmental Red Flags and Ages & Stages Third Edition (ASQ-3) questionnaires for developmental assessment.
Main Results:
- The study included 46 parents of 55 babies (31 CAPA-IVM, 24 natural conception).
- Mean follow-up age was 15 months; baseline characteristics were comparable between groups.
- No significant differences were observed in abnormal ASQ-3 scores (6.5% vs. 20.8%) or developmental red flags (9.7% vs. 4.2%) between CAPA-IVM and natural conception groups.
Conclusions:
- Capacitation-in vitro maturation (CAPA-IVM) does not appear to have a significant impact on childhood physical and mental development.
- Developmental outcomes in children born after CAPA-IVM are comparable to those conceived naturally.
Purpose:
IVM preceded by a prematuration step (capacitation [CAPA]-IVM) improves the acquisition of oocyte developmental competence and can enhance embryo quality. There is currently no follow-up data on babies born from CAPA-IVM. This study investigated developmental outcomes in children born after CAPA-IVM versus natural conception.
Methods:
This prospective cohort study was conducted at a fertility clinic in Vietnam in August/September 2019. Children born after CAPA-IVM were propensity score-matched with those born after natural conception. All parents were asked to complete the Developmental Red Flags and Ages & Stages Third Edition (ASQ-3) questionnaires.
Results:
A total of 46 parents (23 in each group) of 55 babies (31 CAPA-IVM and 24 natural conception) were included in the study. Baseline characteristics, including mother's age and body mass index, gestational age at delivery, and birth weight, were comparable. The mean age of children at the end of follow-up was 15 months. The overall proportion of children with any abnormal ASQ-3 score was 6.5% in the CAPA-IVM group and 20.8% in the natural conception group (p = 0.24). The proportion of children with a developmental red flag did not differ significantly between the CAPA-IVM and natural conception groups (9.7% vs. 4.2%; p = 0.80).
Conclusions:
The use of CAPA-IVM did not have any significant impact on childhood physical and mental development compared with children born as a result of natural conception.
