Related Experiment Video
Updated: Sep 5, 2025
08:24
Injections of Lipopolysaccharide into Mice to Mimic Entrance of Microbial-derived Products After Intestinal Barrier Breach
Published on: May 2, 2018
19.8K
Gut Microbiota Association with Diverticular Disease Pathogenesis and Progression: A Systematic Review
Elisa Reitano1, Elisa Francone2,3, Elisa Bona4
1Department of Translational Medicine, Maggiore Della Carità University Hospital, University of Eastern Piedmont, Via Solaroli 17, 28100, Novara, Italy. elisa.reitano@live.it.
Digestive Diseases and Sciences
|July 7, 2022
Summary
The intestinal microbiome may play a role in diverticular disease (DD) and acute diverticulitis (AD). Enterobacteriaceae and Bifidobacteria were the most associated microbiota, but more research is needed.
Area of Science:
- Gastroenterology
- Microbiology
- Public Health
Background:
- Diverticular disease (DD) is a prevalent condition in Western countries.
- Emerging evidence links the intestinal microbiome to various diseases, including DD and acute diverticulitis (AD).
- Understanding the microbiome's role in DD pathogenesis is crucial for developing targeted therapies.
Approach:
- A systematic review was conducted following PRISMA guidelines.
- Literature search performed across multiple databases (Medline, Scopus, Embase, etc.).
- Included studies focused on patients with any stage of diverticular disease; quality assessed using the Newcastle-Ottawa scale.
Key Points:
- Nine studies were included in the review.
- Only one study focused on acute diverticulitis (AD); others examined DD without acute inflammation.
- Enterobacteriaceae and Bifidobacteria were identified as the most frequently associated microbiota with DD.
Conclusions:
- Significant heterogeneity exists among the included studies regarding population characteristics and sampling methods.
- Further research is essential to elucidate the precise role of the intestinal microbiome in colonic diverticulitis.
- Clarifying the microbiome's involvement could lead to novel therapeutic strategies for this widespread condition.
Related Concept Videos
01:17Chronic Bowel Disorders: Introduction
534
Chronic bowel diseases are a group of long-term conditions affecting the digestive tract, characterized by inflammation and damage to the gut lining. These conditions primarily include irritable bowel syndrome and inflammatory bowel disease.
Irritable Bowel Syndrome (IBS) is a common disorder affecting the gastrointestinal tract. The distinctive feature is recurrent abdominal pain associated with altered bowel movements, manifesting as constipation, diarrhea, or fluctuating between both. The...
Irritable Bowel Syndrome (IBS) is a common disorder affecting the gastrointestinal tract. The distinctive feature is recurrent abdominal pain associated with altered bowel movements, manifesting as constipation, diarrhea, or fluctuating between both. The...
534
01:27Inflammatory Bowel Disease I: Ulcerative Colitis
305
Introduction
Inflammatory bowel disease, or IBD, encompasses a group of disorders characterized by chronic inflammation or ulceration of the gastrointestinal tract.
Risk Factors
The exact cause of IBD remains unclear, although it is believed to be due to a mix of genetic, environmental, microbial, and immune factors. Genetic factors are significant in determining susceptibility to IBD, with family history being a critical risk factor. Individuals with a first-degree relative who has IBD are at...
Inflammatory bowel disease, or IBD, encompasses a group of disorders characterized by chronic inflammation or ulceration of the gastrointestinal tract.
Risk Factors
The exact cause of IBD remains unclear, although it is believed to be due to a mix of genetic, environmental, microbial, and immune factors. Genetic factors are significant in determining susceptibility to IBD, with family history being a critical risk factor. Individuals with a first-degree relative who has IBD are at...
305
01:30Inflammatory Bowel Disease II: Crohn's Disease
369
Introduction
Inflammatory bowel disease, commonly known as IBD, refers to a collection of disorders that lead to persistent inflammation of the gastrointestinal tract. The two types of IBD are ulcerative colitis, which impacts the colon, and Crohn's disease, which can involve any part of the gastrointestinal segment.
Crohn's disease
Crohn's disease is a chronic, systemic inflammatory bowel disease (IBD) that predominantly affects the gastrointestinal tract. It is marked by...
Inflammatory bowel disease, commonly known as IBD, refers to a collection of disorders that lead to persistent inflammation of the gastrointestinal tract. The two types of IBD are ulcerative colitis, which impacts the colon, and Crohn's disease, which can involve any part of the gastrointestinal segment.
Crohn's disease
Crohn's disease is a chronic, systemic inflammatory bowel disease (IBD) that predominantly affects the gastrointestinal tract. It is marked by...
369
01:28Peptic Ulcer Disease II: Pathophysiology
801
Peptic Ulcer Disease (PUD) is characterized by the development of ulcers in the stomach or duodenal mucosa. Its pathophysiology is complex, involving a balance between damaging and protective elements.
Damaging agents such as Helicobacter pylori, gastric acid, pepsin, and nonsteroidal anti-inflammatory drugs (NSAIDs) can weaken the mucosal defense, allowing hydrogen ions to infiltrate back and harm epithelial cells.
Damaging agents such as Helicobacter pylori, gastric acid, pepsin, and nonsteroidal anti-inflammatory drugs (NSAIDs) can weaken the mucosal defense, allowing hydrogen ions to infiltrate back and harm epithelial cells.
801
01:30Irritable Bowel Syndrome II: Clinical Features and Diagnostic Evaluation
229
Irritable Bowel Syndrome II: Clinical Features and Diagnostic Evaluation
Irritable Bowel Syndrome (IBS) is classified into subtypes based on the predominant bowel habits as determined by the Bristol Stool Form Scale (BSFS). The subtypes are:
Irritable Bowel Syndrome (IBS) is classified into subtypes based on the predominant bowel habits as determined by the Bristol Stool Form Scale (BSFS). The subtypes are:
229
01:30Inflammatory Bowel Disease III: Diagnostic Studies and Management I-Nutritional Therapy
403
Various diagnostic tests are employed in the diagnostic process for Inflammatory Bowel Disease (IBD), particularly to differentiate between Crohn's disease and ulcerative colitis.
Diagnostic studies
A colonoscopy is the definitive screening test, distinguishing ulcerative colitis from other colon diseases with similar symptoms. During a colonoscopy test, inflamed mucosa with exudate ulcerations can be observed, and biopsies are taken to determine the histologic characteristics of the...
Diagnostic studies
A colonoscopy is the definitive screening test, distinguishing ulcerative colitis from other colon diseases with similar symptoms. During a colonoscopy test, inflamed mucosa with exudate ulcerations can be observed, and biopsies are taken to determine the histologic characteristics of the...
403