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Fast-dissolving oral films containing dextromethorphan/phenylephrine for sinusitis treatment: formulation,
Mozhgan Moonesan1, Fariba Ganji2, Arezoo Soroushnia3
1Biomedical Engineering Group, Chemical Engineering Department, Tarbiat Modares University, P.O. Box: 14115-114, Tehran, Iran.
Progress in Biomaterials
|July 7, 2022
Summary
This study developed an optimized fast-dissolving oral film for cough relief using phenylephrine hydrochloride and dextromethorphan hydrobromide. The patient-friendly film formulation ensures rapid drug release and effective symptom management.
Area of Science:
- Pharmaceutical Technology
- Drug Delivery Systems
- Formulation Science
Background:
- Developing patient-friendly dosage forms is crucial for improving medication adherence.
- Fast-dissolving oral films offer an alternative delivery route for active pharmaceutical ingredients.
- Antitussive medications like phenylephrine and dextromethorphan require effective and rapid delivery systems.
Purpose of the Study:
- To formulate and optimize a patient-friendly, fast-dissolving oral film containing phenylephrine hydrochloride and dextromethorphan hydrobromide.
- To investigate the impact of key formulation components on the performance of the oral films.
- To establish an optimal formulation with desired physicochemical and mechanical properties.
Main Methods:
- Utilized hydroxypropylmethyl cellulose (HPMC) grades (E5, E50) as film-forming polymers via solvent-casting.
- Incorporated polyethylene glycol (PEG) as a plasticizer, aspartame as a sweetener, and microcrystalline cellulose as a disintegrant.
- Employed response surface methodology with a central composite design to optimize formulation parameters and evaluate responses like disintegration time and dissolution.
Main Results:
- An optimized formulation was successfully designed and prepared, containing specific percentages of HPMC grades, phenylephrine hydrochloride, dextromethorphan hydrobromide, and PEG.
- The optimal film exhibited favorable characteristics including appropriate thickness, surface pH, rapid disintegration, and high dissolution percentage.
- Key formulation factors (HPMC E50 content and PEG percentage) were identified as significant in achieving the desired film properties.
Conclusions:
- A robust and optimized fast-dissolving oral film formulation for phenylephrine hydrochloride and dextromethorphan hydrobromide was developed.
- The study demonstrated the successful application of response surface methodology in optimizing complex oral film formulations.
- The developed film offers a promising patient-friendly alternative for the effective management of cough symptoms.
Keywords:
Dextromethorphan hydrobromideFast-dissolving oral filmOptimizationPhenylephrine hydrochlorideSinusitisMore Related Videos
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