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Related Experiment Video

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Polar Histogram Visualization of Acute Stress Disorder Scale Scores for Comprehensive Clinical Assessment

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Harmonizing PTSD severity scales across instruments and sites.

Eamonn Kennedy¹, Emily L Dennis¹, Hannah M Lindsey¹

¹Department of Neurology, University of Utah School of Medicine.

Neuropsychology

|July 7, 2022

Summary

This study developed methods to equate scores across different posttraumatic stress disorder (PTSD) measures. Harmonization and covariate adjustments significantly improved data synthesis for PTSD symptom severity.

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Area of Science:

Psychiatry and Behavioral Science
Data Science
Statistical Modeling

Background:

Assessing posttraumatic stress disorder (PTSD) utilizes diverse instruments, posing challenges for consistent data analysis and synthesis.
A multisite mega-analysis is needed to establish quantitative methods for comparing PTSD severity scores across different assessment tools.

Purpose of the Study:

To derive quantitative recommendations for equating scores across various measures of posttraumatic stress disorder (PTSD) severity.
To address challenges in data synthesis arising from the variety of PTSD assessment instruments.

Main Methods:

Utilized Empirical Bayes harmonization and linear models to mitigate site and covariate effects.
Developed quadratic models for score conversion across PTSD assessments, employing bootstrapping and testing on hold-out data.
Aggregated data from 17 sources, resulting in a sample of 5,634 individuals assessed for PTSD symptoms.

Main Results:

Harmonization and covariate adjustments significantly enhanced the inference of scores across instruments.
Cross-dataset variance was substantially reduced by harmonization (28%, p < .001).
Models for converting scores demonstrated excellent fit (median R² = 0.985) with a low average root mean squared error (1.46) on sum scores.

Conclusions:

Developed methods enable PTSD symptom severity to be standardized across multiple scales.
The study provides empirical insights into the utility of harmonization in behavioral science research.
Facilitates more robust meta-analyses and data comparisons in PTSD research.