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Comprehensiveness of Testing Among Herpes Simplex Virus Infected Infants: A Multicenter Cohort Study

Christopher M Pruitt1, Lise E Nigrovic2, Stephen B Freedman3

  • 1From the Department of Pediatrics, Medical University of South Carolina, Charleston, South Carolina.

The Pediatric Infectious Disease Journal
|July 7, 2022
PubMed

Insights

Infant herpes simplex virus (HSV) testing is often incomplete, with less than 20% of infants receiving all recommended diagnostic tests. This highlights a critical gap in adherence to guidelines for diagnosing this serious infection in newborns.

Area of Science:

  • Pediatric infectious diseases
  • Neonatal care
  • Virology

Background:

  • Herpes simplex virus (HSV) poses a significant risk to infants.
  • Established guidelines exist for comprehensive HSV testing in neonates.

Purpose of the Study:

  • To evaluate the comprehensiveness of HSV testing practices in infants with confirmed HSV disease.
  • To identify gaps in adherence to current HSV testing recommendations.

Main Methods:

  • A multi-center study involving 23 institutions.
  • Analysis of testing data for 112 infants diagnosed with confirmed HSV disease.

Main Results:

  • Less than one-fifth (approximately 20%) of infants with confirmed HSV disease received all recommended diagnostic tests.
  • Significant variability in testing practices across different centers was observed.

Conclusions:

  • Current HSV testing practices in infants frequently fall short of recommended guidelines.
  • There is a critical need to improve awareness and adherence to HSV testing protocols for vulnerable infants.

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