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Detection of the Genome and Transcripts of a Persistent DNA Virus in Neuronal Tissues by Fluorescent In situ Hybridization Combined with Immunostaining

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Comprehensiveness of Testing Among Herpes Simplex Virus Infected Infants: A Multicenter Cohort Study.

Christopher M Pruitt¹, Lise E Nigrovic², Stephen B Freedman³

¹From the Department of Pediatrics, Medical University of South Carolina, Charleston, South Carolina.

The Pediatric Infectious Disease Journal

|July 7, 2022

Summary

Infant herpes simplex virus (HSV) testing is often incomplete, with less than 20% of infants receiving all recommended diagnostic tests. This highlights a critical gap in adherence to guidelines for diagnosing this serious infection in newborns.

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Area of Science:

Pediatric infectious diseases
Neonatal care
Virology

Background:

Herpes simplex virus (HSV) poses a significant risk to infants.
Established guidelines exist for comprehensive HSV testing in neonates.

Purpose of the Study:

To evaluate the comprehensiveness of HSV testing practices in infants with confirmed HSV disease.
To identify gaps in adherence to current HSV testing recommendations.

Main Methods:

A multi-center study involving 23 institutions.
Analysis of testing data for 112 infants diagnosed with confirmed HSV disease.

Main Results:

Less than one-fifth (approximately 20%) of infants with confirmed HSV disease received all recommended diagnostic tests.
Significant variability in testing practices across different centers was observed.

Conclusions:

Current HSV testing practices in infants frequently fall short of recommended guidelines.
There is a critical need to improve awareness and adherence to HSV testing protocols for vulnerable infants.