Incidence and Risk Factors of Left Ventricular Thrombus in Acute ST-Segment Elevation Myocardial Infarction Treated

Related Experiment Video

Updated: Sep 5, 2025

Left Anterior Descending Coronary Artery Ligation for Ischemia-Reperfusion Research: Model Improvement via Technical Modifications and Quality Control
05:41

Left Anterior Descending Coronary Artery Ligation for Ischemia-Reperfusion Research: Model Improvement via Technical Modifications and Quality Control

Published on: December 16, 2022

3.6K

Pei Wang1, Xudong Ye2, Dongdong Yan3

  • 1The First Clinical Medical College of Lanzhou University, Lanzhou, China, pwang1996@163.com.

Medical Principles and Practice : International Journal of the Kuwait University, Health Science Centre
|July 7, 2022
PubMed

Insights

Left ventricular thrombosis (LVT) occurs in 4% of ST-segment elevation myocardial infarction (STEMI) patients after primary percutaneous coronary intervention (PCI). Anterior STEMI and reduced left ventricular ejection fraction are key risk factors for LVT.

Area of Science:

  • Cardiology
  • Interventional Cardiology

Background:

  • Left ventricular thrombosis (LVT) is a significant complication following acute ST-segment elevation myocardial infarction (STEMI).
  • Primary percutaneous coronary intervention (PCI) is the standard treatment for STEMI, but LVT remains a concern.
  • Understanding the incidence and risk factors of LVT post-PCI is crucial for patient management.

Approach:

  • A comprehensive meta-analysis was conducted, searching major databases (PubMed, Embase, Cochrane Library, Web of Science) for studies from 2001 to 2022.
  • Utilized random-effects and fixed-effects models to estimate pooled incidence, mean difference (MD), and odds ratios (OR) with 95% confidence intervals (CI).
  • Review Manager 5.4 software facilitated the meta-analysis process.

Key Points:

  • The overall incidence of LVT in STEMI patients undergoing primary PCI was found to be 4%.
  • Anterior STEMI showed a significantly higher incidence of LVT (10.0%).
  • Identified risk factors for LVT include anterior STEMI (OR=11.93), left anterior descending-related infarct (OR=6.85), left ventricular wall motion abnormalities (OR=7.53), and lower post-PCI left ventricular ejection fraction (LVEF) (MD=13.78).

Conclusions:

  • The incidence of LVT after acute STEMI in the PCI era remains substantial.
  • This meta-analysis provides critical insights into patient populations at higher risk for post-PCI LVT.
  • Findings can inform the design of future prospective randomized controlled trials for LVT prevention and management.
Abstract

Keywords:
Left ventricular thrombusMeta-analysisMyocardial infarctionPercutaneous coronary intervention

More Related Videos

Postconditioning with Lactate-enriched Blood for Cardioprotection in ST-segment Elevation Myocardial Infarction05:26

Postconditioning with Lactate-enriched Blood for Cardioprotection in ST-segment Elevation Myocardial Infarction

Published on: May 28, 2019

9.4K
Cardiac Magnetic Resonance for the Evaluation of Suspected Cardiac Thrombus: Conventional and Emerging Techniques06:29

Cardiac Magnetic Resonance for the Evaluation of Suspected Cardiac Thrombus: Conventional and Emerging Techniques

Published on: June 11, 2019

10.5K

Related Concept Videos

Acute Coronary Syndrome I: Introduction01:30

Acute Coronary Syndrome I: Introduction

Acute Coronary Syndrome (ACS) encompasses a spectrum of heart conditions caused by sudden obstruction of coronary arteries, typically resulting from the rupture of an atherosclerotic plaque and subsequent thrombus (blood clot) formation. This obstruction can lead to partial or complete blockage of blood flow, causing varying degrees of myocardial ischemia or infarction.ACS includes the following clinical entities:Unstable Angina (UA)Non-ST-Elevation Myocardial Infarction (NSTEMI)ST-Elevation...
70
Pulmonary Embolism II: Diagnostic Studies and Interprofessional Care01:29

Pulmonary Embolism II: Diagnostic Studies and Interprofessional Care

Diagnosing Pulmonary EmbolismDiagnosing pulmonary embolism (PE) involves clinical assessment and advanced imaging tests. The preferred diagnostic tool is the spiral (helical) CT scan or CT angiography (CTA), which uses intravenous contrast media to visualize the pulmonary vasculature and identify emboli.A ventilation-perfusion (V/Q) scan is an alternative for patients unable to receive contrast media. This scan includes both perfusion and ventilation scanning. Perfusion scanning involves...
40
Venous Thrombosis III: Interprofessional Care01:29

Venous Thrombosis III: Interprofessional Care

Venous thrombosis requires effective prevention and treatment strategies to improve patient outcomes and reduce potential complications.Prevention StrategiesHealthcare providers must prioritize preventing venous thromboembolism (VTE) for all adult patients upon admission. Interventions depend on bleeding and thrombosis risk, medical history, current medications, diagnoses, planned procedures, and patient preferences. Patients on bed rest should change positions every two hours and, if not...
21
Acute Coronary Syndrome III: Diagnostic Studies01:30

Acute Coronary Syndrome III: Diagnostic Studies

Diagnosing acute coronary syndrome or ACS begins with a thorough patient history. Notable symptoms include central, crushing chest pain radiating to the left arm, neck, jaw, or back, along with shortness of breath, sweating (diaphoresis), nausea, vomiting, dizziness, and palpitations.It is crucial to note any history of cardiac illnesses and assess risk factors, including age, gender, smoking, hypertension, diabetes, hyperlipidemia, and a sedentary lifestyle.During physical examination, vital...
21
Venous Thrombosis I: Introduction01:30

Venous Thrombosis I: Introduction

Venous thrombosis, the most common disorder of the veins, involves the formation of a thrombus or blood clot associated with vein inflammation. It can be classified as either superficial vein thrombosis or deep vein thrombosis.Superficial Vein Thrombosis: This involves the formation of a thrombus in a superficial vein, usually the greater or lesser saphenous vein. Though less severe than deep vein thrombosis (DVT), SVT can lead to complications if untreated.Deep Vein Thrombosis (DVT): This...
39
Cardiac Catheterization III: Left Heart Catheterization01:24

Cardiac Catheterization III: Left Heart Catheterization

Left heart catheterization is an invasive diagnostic procedure used to evaluate the function and structure of the left side of the heart. It is generally performed to diagnose and treat cardiovascular conditions such as valve abnormalities, coronary artery disease, and congenital heart defects.Diagnostic and therapeutic purposesLeft heart catheterization serves various diagnostic and therapeutic purposes, including:Assessing coronary artery bypass grafts.Evaluating coronary artery disease in...
199