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Related Concept Videos

Genome-wide Association Studies-GWAS01:11

Genome-wide Association Studies-GWAS

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Genome-wide association studies or GWAS are used to identify whether common SNPs are associated with certain diseases. Suppose specific SNPs are more frequently observed in individuals with a particular disease than those without the disease. In that case, those SNPs are said to be associated with the disease. Chi-square analysis is performed to check the probability of the allele likely to be associated with the disease.
GWAS does not require the identification of the target gene involved in...
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Related Experiment Video

Updated: Sep 5, 2025

Glycemic Impact on Knee Osteoarthritis Symptoms on Physical, Radiographic, and Inflammatory Markers among Individuals Aged 50 and Over with Diabetes
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Glycemic Impact on Knee Osteoarthritis Symptoms on Physical, Radiographic, and Inflammatory Markers among Individuals Aged 50 and Over with Diabetes

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Osteoarthritis & stroke: a bidirectional mendelian randomization study.

H Zhao1, J Zhu1, L Ju1

  • 1School of Public Health, Hangzhou Medical College, Hangzhou 310053, China.

Osteoarthritis and Cartilage
|July 7, 2022
PubMed
Summary
This summary is machine-generated.

This study found that hip osteoarthritis is a risk factor for stroke, including ischemic stroke and small vessel ischemic stroke. However, stroke did not appear to cause osteoarthritis.

Keywords:
BidirectionalMendelian randomizationOsteoarthritisStroke

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Area of Science:

  • Genetics
  • Epidemiology
  • Neurology

Background:

  • The relationship between osteoarthritis (OA) and stroke is not well understood.
  • Previous epidemiological studies have yielded inconclusive results regarding a causal link.

Purpose of the Study:

  • To investigate the potential causal relationship between osteoarthritis and stroke using a bidirectional Mendelian randomization approach.
  • To determine if osteoarthritis is a risk factor for stroke or vice versa.

Main Methods:

  • A two-sample Mendelian randomization (MR) study utilizing summary-level data from large genome-wide association studies (GWAS).
  • Data for osteoarthritis (any site, knee, hip) and stroke (overall, ischemic stroke, intracerebral hemorrhage) were obtained from UK Biobank, Arthritis Research UK, and MEGASTROKE consortium.
  • Inverse variance weighted (IVW) method was the primary analysis, supplemented by MR-Egger, weighted median, and other sensitivity analyses.

Main Results:

  • A significant association was found between higher risk of hip osteoarthritis and overall stroke, ischemic stroke, and small vessel ischemic stroke.
  • Odds ratios indicated increased risk for stroke with hip OA presence.
  • No evidence of a causal effect of stroke on osteoarthritis was detected in the reverse MR analyses.

Conclusions:

  • Genetic evidence suggests that hip osteoarthritis may be a risk factor for overall stroke, ischemic stroke, and small vessel ischemic stroke.
  • Further research is needed to explore the biological mechanisms underlying the causal link between site-specific osteoarthritis and stroke subtypes.