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Updated: Sep 5, 2025

Density Gradient Multilayered Polymerization DGMP: A Novel Technique for Creating Multi-compartment, Customizable Scaffolds for Tissue Engineering

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Dextrans and dextran derivatives as polyelectrolytes in layer-by-layer processing materials - A review.

Aurore Delvart¹, Céline Moreau¹, Bernard Cathala¹

¹INRAE, UR1268 BIA, F-44316 Nantes, France.

Carbohydrate Polymers

|July 7, 2022

Summary

Bacterial polysaccharides like dextrans are used in layer-by-layer (LbL) assemblies to create functional, biodegradable nano- and microstructures. These dextran-based multilayers show promise for advanced biomedical applications, particularly in drug delivery systems.

Keywords:

Capsules Dextran derivatives Dextrans Layer-by-layer Multilayers Nanomaterials Thin films

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Last Updated: Sep 5, 2025

Density Gradient Multilayered Polymerization DGMP: A Novel Technique for Creating Multi-compartment, Customizable Scaffolds for Tissue Engineering

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Layer-by-layer Synthesis and Transfer of Freestanding Conjugated Microporous Polymer Nanomembranes

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Published on: December 15, 2015

Area of Science:

Materials Science
Biotechnology
Polymer Chemistry

Background:

Layer-by-layer (LbL) technique offers a versatile method for fabricating multilayered nano- and microstructures.
Natural materials, particularly polysaccharides, are gaining traction as sustainable alternatives in materials fabrication.
Bacterial polysaccharides, such as dextrans and their derivatives, present unique properties for advanced material design.

Purpose of the Study:

To review the application of dextrans and dextran derivatives in LbL assemblies.
To explore the principles, methods, and critical parameters for forming dextran-based multilayers.
To highlight the potential of these engineered multilayers in biomedical applications, especially drug delivery.

Main Methods:

Literature review of studies employing dextrans and dextran derivatives in LbL fabrication.
Analysis of assembly conditions influencing multilayer structure and properties.
Investigation of the functionalization and application of resulting nanoobjects.

Main Results:

Dextrans and their derivatives enable the straightforward creation of biodegradable and biocompatible multilayers via LbL.
Assembly conditions significantly influence the internal structure and physicochemical properties of the multilayers.
Engineered dextran-based nanoobjects exhibit specific and stimuli-responsive characteristics.

Conclusions:

Dextran-based LbL multilayers are a promising platform for developing advanced functional materials.
The controlled fabrication of these materials is key to tailoring their properties for specific applications.
These dextran multilayers hold significant potential for innovative drug delivery systems and other biomedical uses.