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Encapsulation of Cancer Therapeutic Agent Dacarbazine Using Nanostructured Lipid Carrier

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Developing DHA microcapsules using linear dextrin aggregates of different chain length distributions.

Jintao Hu¹, Nan Ma¹, Xiong Fu¹

¹SCUT-Zhuhai Institute of Modern Industrial Innovation, School of Food Science and Engineering, South China University of Technology, Guangzhou, China.

Carbohydrate Polymers

|July 7, 2022

Summary

This summary is machine-generated.

Novel linear dextrin aggregates (LDAs) effectively encapsulate docosahexaenoic acid (DHA). Specific chain length distributions in LDAs enhance encapsulation efficiency and DHA stability in microcapsules.

Keywords:

Complexation Degree of polymerization Docosahexaenoic acid Molecular dynamic simulations Ordered structures

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Area of Science:

Food Science and Technology
Materials Science
Biochemistry

Background:

Docosahexaenoic acid (DHA) is a vital omega-3 fatty acid with significant health benefits.
DHA is prone to oxidation, necessitating effective encapsulation strategies for its preservation and delivery.
Starch-based materials offer a promising avenue for developing sustainable and biocompatible encapsulation systems.

Purpose of the Study:

To develop and characterize novel linear dextrin aggregates (LDAs) for encapsulating docosahexaenoic acid (DHA).
To investigate the impact of LDA chain length distribution (CLD) on encapsulation efficiency and DHA stability.
To optimize LDA composition for superior microcapsule performance.

Main Methods:

High amylose corn starch was subjected to acid hydrolysis and enzymatic debranching to produce LDAs with varied CLDs.
Microcapsules were prepared using LDAs for DHA encapsulation.
Encapsulation efficiency and peroxide value of DHA microcapsules were evaluated.
Molecular dynamic simulations were employed to understand DHA-LDA interactions.

Main Results:

Encapsulation efficiency increased from 68% to 81% with improved intermediate linear dextrin content (DP 10-100).
A decrease of 2 mEq/kg in peroxide value was observed during storage, indicating enhanced DHA stability.
Molecular dynamics simulations identified linear dextrin with DP 15 as having the highest interaction attraction with DHA.
Optimal LDA composition (22% intermediate linear dextrin) yielded 85% encapsulation efficiency and a peroxide value of 10 mEq/kg.

Conclusions:

Linear dextrin aggregates with specific chain length distributions are effective for creating high-performance DHA microcapsules.
Optimizing LDA composition enhances both encapsulation efficiency and oxidative stability of DHA.
This study presents a novel starch-based approach for preserving and delivering sensitive bioactive lipids like DHA.