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Updated: Sep 5, 2025
![[DPEPhosbcpCu]PF6: A General and Broadly Applicable Copper-Based Photoredox Catalyst](/_next/image?url=https%3A%2F%2Fcloudfront.jove.com%2FCDNSource%2Fteasers%2F59739.jpg&w=3840&q=50)
[DPEPhosbcpCu]PF6: A General and Broadly Applicable Copper-Based Photoredox Catalyst
Published on: May 21, 2019
Copper- and Chiral Nitroxide-Catalyzed Oxidative Kinetic Resolution of Axially Chiral N-Arylpyrroles
Lenin Kumar Verdhi1, Natalia Fridman2, Alex M Szpilman1
1Department of Chemical Sciences, Ariel University, Ariel 4070000, Israel.
Abstract:
A readily prepared C2-symmetric, α-hydrogen-substituted chiral hydroxylamine serves as a precatalyst to generate a chiral nitroxide in situ. This chiral nitroxide catalyst in combination with a copper co-catalyst functions as an oxidant for an unprecedented enantioselective oxidative kinetic resolution (OKR) of racemic axially chiral N-arylpyrrole alcohols using atmospheric oxygen as an environmentally friendly terminal oxidant. The OKR process provides the axially chiral N-arylpyrroles in er up to 3.5:96.5 and with s factors up to 24.
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