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Quantification of Atherosclerotic Plaque Activity and Vascular Inflammation using [18-F] Fluorodeoxyglucose Positron Emission Tomography/Computed Tomography FDG-PET/CT
10:02

Quantification of Atherosclerotic Plaque Activity and Vascular Inflammation using [18-F] Fluorodeoxyglucose Positron Emission Tomography/Computed Tomography FDG-PET/CT

Published on: May 2, 2012

18.4K

Ongoing vascular inflammation evaluated by 18F-fluorodeoxyglucose positron emission tomography in patients long after

Kenji Suda1,2, Nobuhiro Tahara3,4, Munehisa Bekki5

  • 1Department of Pediatrics and Child Health, Kurume University School of Medicine, Kurume, Japan. suda_kenji@med.kurume-u.ac.jp.

Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology
|July 7, 2022
PubMed

Insights

Ongoing vascular inflammation persists long after Kawasaki disease (KD), particularly in patients with giant coronary artery aneurysms (gCAAs). This highlights the need for continued monitoring in severe KD cases.

Area of Science:

  • Cardiovascular Medicine
  • Pediatric Cardiology
  • Nuclear Medicine

Background:

  • Kawasaki disease (KD) can lead to coronary artery aneurysms (CAAs).
  • The presence of ongoing vascular inflammation in KD patients with CAAs is not fully understood.
  • Severe KD may result in giant CAAs (gCAAs).

Purpose of the Study:

  • To investigate persistent vascular inflammation in patients with Kawasaki disease-associated coronary artery aneurysms (CAAs).
  • To compare vascular inflammation levels between patients with giant CAAs (gCAAs) and smaller CAAs (smCAAs).

Main Methods:

  • 26 KD patients (15 gCAA, 11 smCAA) underwent CT and 18F-FDG PET.
  • Coronary and thoracic aorta target-to-background ratios (CaTBR, TaTBR) were measured.
  • Vascular inflammation markers were correlated with CAA size and metabolic risk factors.

Main Results:

  • CaTBR and TaTBR were significantly higher in gCAA patients compared to smCAA patients.
  • Elevated vascular inflammation was observed even in patients without metabolic risk factors.
  • Acute phase CAA size positively correlated with both CaTBR and TaTBR.

Conclusions:

  • Ongoing vascular inflammation is present long after Kawasaki disease, especially in severe cases with gCAAs.
  • Vascular inflammation markers correlate with initial aneurysm severity.
  • These findings suggest the need for continued surveillance in KD patients with significant CAAs.
Abstract

Keywords:
CADPETinflammationothers

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