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Related Experiment Videos

Copper and the estradiol receptor.

J H Fishman, J Fishman

    Biochemical and Biophysical Research Communications
    |April 14, 1987
    PubMed
    Summary
    This summary is machine-generated.

    Divalent copper enhances estradiol binding to uterine receptors in rats. An endogenous substance inhibits this copper effect, and is also found in human breast tissue and tumors.

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    Area of Science:

    • Biochemistry
    • Endocrinology
    • Molecular Biology

    Background:

    • Copper is an essential element for life.
    • Estrogen action is crucial in biological systems.
    • The precise role of copper in estrogen mechanisms is not fully understood.

    Purpose of the Study:

    • To investigate the link between copper and estrogen action.
    • To elucidate the mechanism by which copper influences estradiol binding.

    Main Methods:

    • Experiments were conducted using rat uterine cytosols.
    • Estradiol binding to receptors was measured at 37°C.
    • Hydroxylapatite column fractionation was used to isolate substances.

    Main Results:

    Related Experiment Videos

  • Divalent copper significantly increased estradiol binding to receptors.
  • An endogenous substance from uterine cytosol inhibited the copper-induced effect.
  • This inhibitory substance was also detected in human breast tissue and tumors.

    • Conclusions:

    • Copper plays a role in modulating estrogen receptor binding.
    • An endogenous inhibitor of copper's effect on estrogen action exists.
    • This finding may have implications for understanding human breast tissue and tumors.