Correlation between helicobacter pylori infection and iron deficiency in children
Yuanda Zhang1, Jing Bi2, Meiying Wang3
1Yuanda Zhang, Department of Nutrition, Baoding Key Laboratory of Clinical Research on Children's Respiratory and Digestive Diseases, Baoding, Hebei, 071000, P.R. China.
Insights
Helicobacter pylori infection is not a direct risk factor for iron deficiency in children. Socioeconomic factors significantly influence the development of iron deficiency in pediatric populations.
Area of Science:
- Pediatric Gastroenterology
- Hematology
- Infectious Diseases
Background:
- Iron deficiency (ID) is a prevalent nutritional deficiency in children.
- Helicobacter pylori (Hp) infection is common in children and has been anecdotally linked to ID.
Purpose of the Study:
- To investigate the correlation between Helicobacter pylori (Hp) infection and Iron deficiency (ID) in children.
- To determine if Hp infection is a risk factor for ID in pediatric populations.
Main Methods:
- A cross-sectional study involving 902 children was conducted.
- Children underwent stool Hp antigen and/or 13C-urea breath tests, and blood tests for iron status (Hb, MCV, SF, SI, TIBC).
- Statistical analyses, including logistic regression, were used to assess the relationship between Hp infection and ID, considering socioeconomic factors.
Main Results:
- The incidence of ID and iron deficiency anemia (IDA) was higher in the Hp-positive group compared to the control group (P < 0.05).
- Children with Hp infection showed lower levels of Hb, MCV, SI, and SF, and higher TIBC (P < 0.05).
- Logistic regression indicated that Hp infection was not an independent risk factor for ID; however, older age, maternal education, urban living, and higher family income were protective factors.
Conclusions:
- Helicobacter pylori infection is not a combined risk factor for the development of iron deficiency in children.
- Family socioeconomic factors play a significant role and should be considered when evaluating the link between Hp infection and ID in children.
Objectives:
To investigate the correlation between Helicobacter pylori (Hp) infection and Iron deficiency (ID) in children.
Methods:
This cross-sectional study was conducted at Baoding Children's Hospital from January 2018 to December 2019. A total of one thousand children who came to our hospital for physical examination and met the inclusion criteria were continuously included in this study. All the children were given questionnaires (personal and family social and economic status), a stool Hp antigen test and/or a 13C-urea breath test, as well as measurements of hemoglobin (Hb), mean red blood cell volume (MCV), red blood cell distribution width (RDW), mean corpuscular hemoglobin concentration (MCHC), serum ferritin (SF), serum iron (SI), and total iron binding capacity (TIBC). Children who tested positive for Hp were divided into the Hp group and children who tested negative for Hp were divided into the control group. ID or IDA was diagnosed based on the child's blood test results.
Results:
A total of 902 children met the inclusion criteria, including 194 (21.5%) in the Hp group and 708 (78.5%) in the control group. The incidence of ID and IDA in Hp group was higher than that in control group (2=9.112, 2=4.478; All P < 0.05); The levels of MCV, SI, SF and Hb in Hp group were lower than those in control group (t=5.288; T = 3.864; T = 6.751; T =11.841, all P < 0.05), TIBC level was higher than that of control group (T =7.630, P < 0.05); The levels of MCHC and RDW in THE Hp group were not statistically significant compared with the control group. Logistic regression showed that Hp infection was not a combined risk factor for ID. Older age, higher educational background of the mother, living in the city, and higher family income were the combined protective factors to prevent the occurrence of ID in children.
Conclusion:
Hp infection is not a combined risk factor for the development of ID in children. The influence of family social and economic factors should be taken into consideration when analyzing the correlation between Hp infection and ID.
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