Correlating Ultrasonographic Features of Lymph Nodes During Endobronchial Ultrasound With Final Outcome

Background In clinical practice, metastatic primary lung cancer, TB, and sarcoidosis are the commonest causes of mediastinal lymphadenopathy. Differentiation of malignant from benign causes is essential. The sonographic features seem to correlate with malignancy in head and neck, breast, and cervix cancers and can be used to predict the etiology of lesions. The objective of our study was to assess the utility of different ultrasonographic features in differentiating benign and malignant lymph nodes by endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA). Methods This is a prospective study analysis of all patients above 18 years presenting with mediastinal and hilar adenopathy on computed chest tomography with contrast, undergoing EBUS-TBNA for diagnosis. Lymph node ultrasonographic characteristics such as size, shape, echogenicity, margins, central hilar structure (CHS), and coagulation necrosis sign (CNS) were recorded and compared with histopathology. Results A total of 576 patients underwent the EBUS-TBNA procedure, and a total of 810 lymph nodes were evaluated. Three hundred and forty-eight patients (468 lymph nodes) were malignant; 228 patients (342 lymph nodes) were benign. Heterogeneous echotexture was significantly higher in malignant lymph nodes (<0.001). The multivariate analysis revealed that heterogeneous echotexture was an independent predictor for malignant etiology. Conclusion Heterogeneous echotexture of the lymph node on EBUS was predictive of malignancy. If heterogenicity is observed on EBUS, subsequent sampling of that lymph node might be considered, which may yield a higher diagnostic yield and may reduce the number of lymph nodes requiring sampling and further invasive procedures.