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Association between sarcoidosis and cardiovascular Outcomes: A systematic review and Meta-analysis

Vikash Jaiswal1, Song Peng Ang2, Zouina Sarfraz3

  • 1AMA School Of Medicine, Makati, Philippines.

International Journal of Cardiology. Heart & Vasculature
|July 8, 2022
PubMed

Insights

Patients with sarcoidosis face significantly higher risks of all-cause mortality, ventricular tachycardia, heart failure, and atrial arrhythmias. Early awareness and monitoring for cardiovascular events in sarcoidosis patients are crucial.

Area of Science:

  • Cardiology
  • Pulmonology
  • Public Health

Background:

  • Sarcoidosis is a chronic inflammatory disease with significant morbidity and mortality.
  • Cardiovascular complications in sarcoidosis are not well-documented.
  • This study investigates the association between sarcoidosis and adverse cardiovascular outcomes.

Purpose of the Study:

  • To compare the incidence of adverse cardiovascular outcomes in patients with sarcoidosis versus those without.
  • To quantify the risks of mortality, ventricular tachycardia, heart failure, and atrial arrhythmias in sarcoidosis patients.

Main Methods:

  • A systematic review and meta-analysis of studies published up to March 2022.
  • Databases searched include PubMed, Embase, and Scopus.
  • Outcomes assessed: all-cause mortality (ACM), ventricular tachycardia (VT), heart failure (HF), and atrial arrhythmias (AA).

Main Results:

  • Analysis included 6 studies with over 22 million participants.
  • Sarcoidosis patients had significantly increased all-cause mortality (RR, 2.08).
  • Higher incidence of VT (RR, 15.3), HF (RR, 4.96), and AA (RR, 2.55) observed in sarcoidosis patients.

Conclusions:

  • Patients with sarcoidosis exhibit significantly higher rates of VT, HF, and AA.
  • Cardiovascular events are a significant concern for individuals with sarcoidosis.
  • Clinicians should maintain a high index of suspicion for these adverse cardiovascular events in sarcoidosis patients.
Abstract

Keywords:
AA, Atrial ArrhythmiaACM, All-cause mortalityACS, Acute coronary syndromeAtrial ArrhythmiaCS, Cardiac SarcoidosisCardiovascular outcomesHF, Heart failureHeart FailureICD, Implantable Cardioverter DefibrillatorMI, Myocardial infarctionMortalityNA, Not availableNS, Non-SarcoidosisOR, Odds ratioPathologyRCT, Randomized Controlled TrialSarcoidosisVT, Ventricular TachycardiaVentricular Arrhythmia

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