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[Chemico-enzymatic method of synthesis of mixed oligonucleotides]
Bioorganicheskaia Khimiia
|February 1, 1987
Abstract:
Oligo (ribodeoxyribo)nucleotide d(TGTGTAT)r(GCCAU) was synthesized from oligonucleotide blocks by chemical ligation, the oligoribonucleotide and oligodeoxynucleotide blocks being prepared by enzymatic and chemical synthesis, resp. A general procedure of the hybride duplex strand separation is described.